CAS 5330-29-0

1,6-Hexanediamine, N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-, hydrochloride (1:2)

Description:

1,6-Hexanediamine, N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-, hydrochloride (1:2) is a complex organic compound characterized by its amine functional groups and a quinoline moiety. This substance features a hexanediamine backbone, which contributes to its potential as a building block in various chemical syntheses. The presence of diethyl groups enhances its solubility and alters its reactivity, while the quinoline derivative introduces aromatic characteristics, which may impart biological activity. As a hydrochloride salt, it is typically more stable and soluble in water compared to its free base form. This compound may exhibit properties such as antimicrobial or antitumor activity, making it of interest in pharmaceutical research. Its molecular structure suggests potential applications in drug development, particularly in targeting specific biological pathways. Safety data and handling precautions should be observed, as with any chemical substance, due to potential toxicity associated with amines and quinoline derivatives.

Formula: C₂₁H₃₄ClN₃O

InChI: InChI=1/C21H33N3O.2ClH/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17(3)11-13-23-21(19)20;;/h11,13,15-16,22H,5-10,12,14H2,1-4H3;2*1H

InChI key: InChIKey=AFMFKGVIHLNIEO-UHFFFAOYSA-N

SMILES: N(CCCCCCN(CC)CC)C=1C2=C(C=C(OC)C1)C(C)=CC=N2.Cl

Synonyms:

• N,N-Diethyl-N(sup 1)-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine dihydrochloride
• N,N-Diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine dihydrochloride
• WR 6026 dihydrochloride
• WR 29606
• NSC 2452
• Sitamaquine dihydrochloride
• 1,6-Hexanediamine, N,N-diethyl-N(sup 1)-(6-methoxy-4-methyl-8-quinolinyl)-, dihydrochloride
• 1,6-Hexanediamine, N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-, dihydrochloride
• WR 6026 dihydrochloride
• 8-(6-Diethylaminohexylamino)-6-methoxy-4-methylquinoline dihydrochloride
• WR 6026
• 1,6-Hexanediamine, N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-, hydrochloride (1:2)
• 1,6-Hexanediamine, N,N-diethyl-N′-(6-methoxy-4-methyl-8-quinolinyl)-, dihydrochloride
• Sitamaquine HCl
• N,N-diethyl-N'-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine dihydrochloride
• 8-Quinolinamine, 6-methoxy-N-(4-(2-piperidinyl)butyl)-, dihydrochloride (9CI)
• AI3-24061

Sitamaquine hydrochloride

CAS: 5330-29-0

Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.

Formula: C₂₁H₃₅Cl₂N₃O

Color and Shape: Solid

Molecular weight: 416.43

Ref: TM-T201411