CAS 53446-10-9

Paracetamol-cysteine

Description:

Paracetamol-cysteine, also known as N-acetyl-p-aminophenol-cysteine, is a derivative of paracetamol (acetaminophen) that is formed through the conjugation of paracetamol with cysteine. This compound is characterized by its potential role in detoxification processes, particularly in the liver, where it may help mitigate the effects of paracetamol toxicity. The structure of paracetamol-cysteine includes both the acetaminophen moiety and a cysteine residue, which contributes to its reactivity and biological activity. It is often studied in the context of pharmacology and toxicology, especially regarding its antioxidant properties and its ability to scavenge free radicals. Paracetamol-cysteine may also be involved in various metabolic pathways, influencing the pharmacokinetics of paracetamol itself. While it is not commonly used as a therapeutic agent, understanding its characteristics can provide insights into the metabolism of paracetamol and the mechanisms of drug-induced liver injury. As with any chemical substance, safety and handling precautions should be observed when working with paracetamol-cysteine in laboratory settings.

Formula: C₁₁H₁₄N₂O₄S

InChI: InChI=1S/C11H14N2O4S/c1-6(14)13-7-2-3-9(15)10(4-7)18-5-8(12)11(16)17/h2-4,8,15H,5,12H2,1H3,(H,13,14)(H,16,17)/t8-/m0/s1

InChI key: InChIKey=LLHICPSCVFRWDT-QMMMGPOBSA-N

SMILES: S(C[C@@H](C(O)=O)N)C1=CC(NC(C)=O)=CC=C1O

Synonyms:

• S-(5-Acetamido-2-hydroxyphenyl)cysteine
• S-[5-(Acetylamino)-2-hydroxyphenyl]-L-cysteine
• 3-Cysteinylacetaminophen
• Paracetamol-cysteine
• L-Cysteine, S-[5-(acetylamino)-2-hydroxyphenyl]-

3-Cysteinyl Acetaminophen HCl

CAS: 53446-10-9

Formula: C₁₁H₁₄N₂O₄S·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 270.31 36.46

Ref: 4Z-A-0221

3-Cysteinyl Acetaminophen

CAS: 53446-10-9

Formula: C₁₁H₁₄N₂O₄S

Molecular weight: 270.30

Ref: 4Z-A-0247

3-Cysteinylacetaminophen-D5 (major), Trifluoroacetic Acid Salt

Controlled Product

CAS: 53446-10-9

Applications 3-Cysteinylacetaminophen-D5 (major), Trifluoroacetic Acid Salt is deuterium labeled 3-Cysteinylacetaminophen Trifluoroacetic Acid Salt (C994750), which is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).Minimum isotopic incorporation d-3, no d-0 present. A representative lot has 64% isotopic incorporation at the 6-position, 89% at the 4-position.
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Formula: C₁₁H₉D₅N₂O₄S•C₂HF₃O₂

Color and Shape: Neat

Molecular weight: 389.36

Ref: TR-C994752

3-Cysteinyl Acetaminophen

CAS: 53446-10-9

Formula: C₁₁H₁₄N₂O₄S

Molecular weight: 270.3

Ref: ST-EA-CP-A7035