CAS 5352-63-6

Digoxigenin monodigitoxoside

Description:

Digoxigenin monodigitoxoside is a cardiac glycoside derived from the plant Digitalis, commonly known for its use in treating heart conditions. This compound is characterized by its steroidal structure, which includes a lactone ring and multiple hydroxyl groups, contributing to its biological activity. It exhibits a high affinity for the sodium-potassium ATPase enzyme, leading to increased intracellular calcium levels and enhanced cardiac contractility. The presence of the digitoxose sugar moiety in its structure influences its solubility and bioavailability. Digoxigenin monodigitoxoside is often utilized in biochemical research, particularly in the development of assays and as a labeling agent due to its ability to bind specifically to antibodies. Its stability under physiological conditions makes it suitable for various applications in molecular biology. However, like other cardiac glycosides, it requires careful handling due to its potent effects on cardiac function and potential toxicity at high concentrations.

Formula: C₂₉H₄₄O₈

InChI: InChI=1S/C29H44O8/c1-15-26(33)22(30)13-25(36-15)37-18-6-8-27(2)17(11-18)4-5-20-21(27)12-23(31)28(3)19(7-9-29(20,28)34)16-10-24(32)35-14-16/h10,15,17-23,25-26,30-31,33-34H,4-9,11-14H2,1-3H3/t15-,17-,18+,19-,20-,21+,22+,23-,25+,26-,27+,28+,29+/m1/s1

InChI key: InChIKey=JFSXBMIFXZFKHD-ZDDLGXCGSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C3=CC(=O)OC3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O)[C@@H](C)O6)C5)[H])[H])[H]

Synonyms:

• (3β,5β,12β)-3-[(2,6-Dideoxy-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 5β-Card-20(22)-enolide, 3β-(digitoxosyloxy)-12β,14-dihydroxy-
• 5β-Card-20(22)-enolide, 3β-[(2,6-dideoxy-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-
• <span class="text-smallcaps">D</span>-ribo-Hexopyranoside, digoxigenin-3 2,6-dideoxy-, β-
• Card-20(22)-enolide, 3-((2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
• Card-20(22)-enolide, 3-[(2,6-dideoxy-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Digoxigenin 3-monodigitoxide
• Digoxigenin digitoxoside
• Digoxigenin monodigitoxide
• Digoxigenin monodigitoxoside
• 5β-Card-20(22)-enolide, 3β-[(2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-
• D-ribo-Hexopyranoside, digoxigenin-3 2,6-dideoxy-, β-

Digoxigenin Monodigitoxoside

CAS: 5352-63-6

Digoxigenin monodigitoxoside is a cardiac glycoside metabolite of digoxin and a Na+/K+ ATPase inhibitor.

Formula: C₂₉H₄₄O₈

Color and Shape: Solid

Molecular weight: 520.663

Ref: TM-T36060

Digoxin EP Impurity D

CAS: 5352-63-6

Formula: C₂₉H₄₄O₈

Color and Shape: White To Off-White Solid

Molecular weight: 520.66

Ref: 4Z-D-7511

Digoxigenin Monodigitoxoside

Controlled Product

CAS: 5352-63-6

Applications A metabolite of Digoxin (Dx) (D446575).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fujii, Y., et al.: Clin. Chem., 37, 476 (1991), Salphati, L., et al.: Xenobiotica, 29, 171 (1999), Song, S., et al.: Drug Metab. Dispos., 27, 689 (1999),

Formula: C₂₉H₄₄O₈

Color and Shape: Beige

Molecular weight: 520.65

Ref: TR-D446505

Digoxigenin monodigitoxoside

CAS: 5352-63-6

Digoxigenin monodigitoxoside is a molecule that has been shown to be an excellent substrate for the enzyme, human serum digoxin-conjugating ɣ-glucuronidase. It has been used in vitro as a substrate for rat liver microsomal ɣ-lactamase, and it can be detected in urine samples with high sensitivity. Digoxigenin monodigitoxoside is metabolized by oxidative reactions to form digoxin. The reaction solution can be heated at 60°C for 5 minutes to remove any hydrogen bond activity before use.

Formula: C₂₉H₄₄O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 520.65 g/mol

Ref: 3D-FD21899

Digoxin EP Impurity D

CAS: 5352-63-6

Formula: C₂₉H₄₄O₈

Molecular weight: 520.7

Ref: ST-EA-CP-D1200004