CAS 53632-49-8

(Sar1,Thr8)-Angiotensin II

Description:

(Sar1,Thr8)-Angiotensin II, also known by its CAS number 53632-49-8, is a synthetic analog of the naturally occurring peptide hormone angiotensin II, which plays a crucial role in regulating blood pressure and fluid balance. This compound is characterized by the substitution of sarcosine (Sar) at the first position and threonine (Thr) at the eighth position of the angiotensin II sequence, which alters its biological activity and receptor binding properties. The modification enhances its stability and potency, making it a valuable tool in pharmacological research. (Sar1,Thr8)-Angiotensin II exhibits vasoconstrictive properties, influencing vascular smooth muscle contraction and promoting the release of aldosterone, thereby affecting sodium and water retention. Its unique structure allows for specific interactions with angiotensin receptors, making it useful in studies related to cardiovascular physiology and potential therapeutic applications in hypertension and heart failure. As a peptide, it is typically administered via injection due to its susceptibility to degradation in the gastrointestinal tract.

Formula: C₄₄H₆₉N₁₃O₁₁

Synonyms:

• AngiotensinII, 1-(N-methylglycine)-5-L-isoleucine-8-L-threonine-
• 159: PN: WO02064734SEQID: 159 claimed protein
• Sarthran
• [Sar1,Ile5,Thr8]-angiotensin II
• L-Threonine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
• Sar-Arg-Val-Tyr-Ile-His-Pro-Thr-OH

[Sar1,Thr8]-Angiotensin II

CAS: 53632-49-8

Angiotensin II is a peptide that is produced in the body and has a variety of effects. It is an activator of angiotensin receptors, which are found on cells throughout the body. Angiotensin II also binds to ligand binding sites on the surface of cells, which are called receptors. The receptor-ligand complex activates or inhibits ion channels in the cell membrane, which results in changes in cell function.

Formula: C₄₄H₆₉N₁₃O₁₁

Purity: Min. 95%

Molecular weight: 956.1 g/mol

Ref: 3D-PAN-4102-V

(Sar 1,Thr8)-Angiotensin II

CAS: 53632-49-8

Angiotensin II is a peptide hormone that regulates blood pressure, fluid balance and glucose metabolism. Angiotensin II is synthesized from the precursor angiotensin I by the action of renin and angiotensin converting enzyme (ACE). The biological function of Angiotensin II is mediated through its binding to two major receptors, the angiotensin type 1 receptor (AT1) and the angiotensin type 2 receptor (AT2). AT1 binds with higher affinity to Ang II and mediates most of its effects. AT2 interacts with lower affinity to Ang II and has been implicated in cancer suppression. It also may regulate growth factors and suppress tumorigenesis. There are several types of Ang II receptors including AT1R, AT2R, MasR, and Matk-II. Sar-Arg-Val-Tyr-Ile-His-Pro-Thr-OH is an Ang II analog that selectively blocks renin release

Formula: C₄₄H₆₉N₁₃O₁₁

Purity: Min. 95%

Molecular weight: 956.1 g/mol

Ref: 3D-FS108529