CAS 53643-48-4: Vindesine

Description:Vindesine is a synthetic vinca alkaloid derived from the periwinkle plant, specifically used in the field of oncology. It is primarily characterized by its ability to inhibit microtubule formation, thereby disrupting mitotic spindle assembly during cell division, which makes it effective in targeting rapidly dividing cancer cells. Vindesine is typically administered intravenously and is known for its use in treating various types of cancers, including leukemia and solid tumors. The compound has a complex structure featuring a tetracyclic core, which is essential for its biological activity. Its pharmacokinetics involve metabolism primarily in the liver, and it is excreted through the bile. Common side effects associated with vindesine include myelosuppression, neurotoxicity, and gastrointestinal disturbances. Due to its mechanism of action, it is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy while minimizing resistance. As with all chemotherapeutic agents, careful monitoring and management of side effects are crucial during treatment.

Formula:C₄₃H₅₅N₅O₇

InChI:InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1

InChI key:InChIKey=HHJUWIANJFBDHT-KOTLKJBCSA-N

SMILES:O=C(OC)C1(C=2C=C3C(=CC2OC)N(C)C4C(O)(C(=O)N)C(O)C5(C=CCN6CCC34C65)CC)C=7NC=8C=CC=CC8C7CCN9CC(CC(O)(C9)CC)C1

Synonyms:
1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
3-(Aminocarbonyl)-O<sup>4</sup>-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
Compound 112531
Vincaleukoblastine, 3-(aminocarbonyl)-O<sup>4</sup>-deacetyl-3-de(methoxycarbonyl)-
Vindesin
Vindesina
Vindesine
Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-
3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
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