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CAS 53643-48-4

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Vindesine

Description:
Vindesine is a synthetic vinca alkaloid derived from the periwinkle plant, specifically used in the field of oncology. It is primarily characterized by its ability to inhibit microtubule formation, thereby disrupting mitotic spindle assembly during cell division, which makes it effective in targeting rapidly dividing cancer cells. Vindesine is typically administered intravenously and is known for its use in treating various types of cancers, including leukemia and solid tumors. The compound has a complex structure featuring a tetracyclic core, which is essential for its biological activity. Its pharmacokinetics involve metabolism primarily in the liver, and it is excreted through the bile. Common side effects associated with vindesine include myelosuppression, neurotoxicity, and gastrointestinal disturbances. Due to its mechanism of action, it is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy while minimizing resistance. As with all chemotherapeutic agents, careful monitoring and management of side effects are crucial during treatment.
Formula:C43H55N5O7
InChI:InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1
InChI key:InChIKey=HHJUWIANJFBDHT-KOTLKJBCSA-N
SMILES:C(C)[C@@]12[C@]3([C@]4(C=5C(N(C)[C@]4([C@](C(N)=O)(O)[C@@H]1O)[H])=CC(OC)=C(C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@]9C[C@@](C6)(C[C@](CC)(O)C9)[H])CCN3CC=C2)[H]
Synonyms:
  • 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
  • 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
  • 3-(Aminocarbonyl)-O<sup>4</sup>-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
  • Compound 112531
  • Vincaleukoblastine, 3-(aminocarbonyl)-O<sup>4</sup>-deacetyl-3-de(methoxycarbonyl)-
  • Vindesin
  • Vindesina
  • Vindesine
  • Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-
  • 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
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Found 2 products.
  • Vindesine
    Targetmol
    + Info

    Vindesine

    CAS:
    Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms.
    Formula:C43H55N5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:753.93

    Ref: TM-TN2299

  • Vindesine
    Biopurify
    + Info

    Vindesine

    CAS:
    Formula:C43H55N5O7
    Purity:95%~99%
    Molecular weight:753.941

    Ref: BP-BP1441

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