CAS 53648-31-0

1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1), (1S)-

Description:

1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1), (1S)- is a chemical compound characterized by its complex bicyclic structure, which includes a benzoxazocine moiety. This compound features a tetrahydro configuration, indicating the presence of a saturated ring system, and a methyl group at the 5-position, contributing to its unique properties. The presence of a phenyl group enhances its aromatic characteristics, potentially influencing its reactivity and interaction with biological systems. As a hydrochloride salt, it is typically more soluble in water, which can facilitate its use in various applications, including pharmaceuticals. The (1S)- designation indicates a specific stereochemistry, which can be crucial for its biological activity and interaction with receptors. Overall, this compound may exhibit interesting pharmacological properties, making it a subject of interest in medicinal chemistry and drug development. However, detailed studies would be necessary to fully elucidate its biological effects and potential applications.

Formula: C₁₇H₁₉NO·ClH

InChI: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H/t17-;/m0./s1

InChI key: InChIKey=CNNVSINJDJNHQK-LMOVPXPDSA-N

SMILES: CN1CC=2C([C@@H](OCC1)C3=CC=CC=C3)=CC=CC2.Cl

Synonyms:

• (S)-Nefopam hydrochloride
• (+)-Nefopam hydrochloride
• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1), (1S)-
• (1S)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride
• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride, (S)-
• (S)-3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride
• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride, (1S)-

(+)-Nefopam Hydrochloride

Controlled Product

CAS: 53648-31-0

Applications (+)-Nefopam inhibits the uptake of 5-hydroxytryptamine (5-HT), noradrenaline and dopamine in synaptosomal preparations from rat forebrain, hippocampus and striatum. A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
References Rosland, J. H., et al.: J. Pharm. Pharmacol, 42, 437 (1990); Bassett, et al.: Br. J. Pharmacol., 37, 69 (1969), Klohs, et al.: Arzneim.-Forsch., 22, 132 (1972), Hell, et al.: Drugs, 19, 249 (1980),

Formula: C₁₇H₁₉NO·HCl

Color and Shape: Neat

Molecular weight: 289.8

Ref: TR-N385745