CAS 536709-33-8

(3S,4S,5S,6R)-6-[(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-azetidin-3-yl]propoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid

Description:

The chemical substance with the name "(3S,4S,5S,6R)-6-[(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-azetidin-3-yl]propoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid" and CAS number "536709-33-8" is a complex organic compound characterized by its multi-functional groups and stereochemistry. It features a tetrahydropyran ring, which is a six-membered cyclic ether, and contains multiple hydroxyl (-OH) groups that contribute to its hydrophilicity and potential biological activity. The presence of fluorophenyl groups suggests that it may exhibit specific interactions with biological targets, potentially enhancing its pharmacological properties. The azetidine moiety indicates a structural framework that could be relevant in medicinal chemistry, particularly in the development of therapeutics. The stereochemistry, denoted by the specific S and R configurations, is crucial for the compound's biological activity, as it can influence how the molecule interacts with enzymes or receptors in biological systems. Overall, this compound may have applications in pharmaceuticals, particularly in the treatment of diseases where such structural features are beneficial.

Formula: C₃₀H₂₉F₂NO₉

InChI: InChI=1/C30H29F2NO9/c31-17-5-1-15(2-6-17)22(41-30-26(37)24(35)25(36)27(42-30)29(39)40)14-13-21-23(16-3-11-20(34)12-4-16)33(28(21)38)19-9-7-18(32)8-10-19/h1-12,21-27,30,34-37H,13-14H2,(H,39,40)/t21-,22+,23-,24+,25+,26+,27?,30-/m1/s1

Synonyms:

• Ezetimibe Hydroxy β-D-Glucuronide
• (1S)-1-(4-Fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-3-azetidinyl]propyl beta-D-glucopyranosiduronic acid
• (1S)-1-(4-Fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-3-azetidinyl]propyl -D-Glucopyranosiduronic Acid
• SCH 488128
• EZETIMIBE HYDROXY GLUCURONIDE
• Ezetimibe Hydroxy -D-Glucuronide
• (2S,3S,4S,5R,6R)-6-((S)-1-(4-Fluorophenyl)-3-((2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4
• (1S)-1-(4-Fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-3-azetidinyl]propyl b-D-Glucopyranosiduronic Acid

Benzyl Ezetimibe Diol (Mixture of Diastereomers)

CAS: 536709-33-8

Formula: C₃₁H₃₁F₂NO₃

Color and Shape: Yellow Solid

Molecular weight: 503.59

Ref: 4Z-E-0634

Ezetimibe hydroxy-b-D-glucuronide

CAS: 536709-33-8

Ref: 7W-GC1772

Ezetimibe-d4 Hydroxy Glucuronide

CAS: 536709-33-8

Formula: C₃₀H₂₅D₄F₂NO₉

Molecular weight: 589.58

Ref: 4Z-E-06110

Ezetimibe Hydroxy Glucuronide

CAS: 536709-33-8

Formula: C₃₀H₂₉F₂NO₉

Color and Shape: Off-White To Gray Solid

Molecular weight: 585.56

Ref: 4Z-E-063

Ezetimibe Hydroxy beta-D-Glucuronide

Controlled Product

CAS: 536709-33-8

Applications A metabolite of Ezetimibe. Antilipemic.
References Shah, V., et al.: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Patrick, J., et al.: Drug Metab. Dispos., 30, 430 (2002),

Formula: C₃₀H₂₉F₂NO₉

Color and Shape: Neat

Molecular weight: 585.55

Ref: TR-E975035

Ezetimibe Hydroxy Glucuronide

CAS: 536709-33-8

Formula: C₃₀H₂₉F₂NO₉

Molecular weight: 585.6

Ref: ST-EA-CP-E6066

Ezetimibe hydroxy-b-D-glucuronide

CAS: 536709-33-8

Ezetimibe hydroxy-b-D-glucuronide is an oligosaccharide that can be synthesized from the modified sugar, L-glucuronic acid. It has a molecular weight of 536 and is soluble in water and methanol. This compound has been used in the synthesis of glycosides, saccharides, and polysaccharides. The chemical name for this compound is 1-(2-hydroxyethyl)-3-(((4'-carboxybenzyl)oxy)carbonyl)-2,6-diazaoctane glucuronide. Ezetimibe hydroxy-b-D-glucuronide has been shown to increase the absorption of cholesterol and decrease low density lipoprotein (LDL) levels in the blood by inhibiting intestinal cholesterol absorption.

Formula: C₃₀H₂₉F₂NO₉

Purity: Min. 95%

Molecular weight: 585.55 g/mol

Ref: 3D-ME09937