S39625, with the CAS number 536711-20-3, is a chemical compound that has garnered interest in various fields, particularly in medicinal chemistry and pharmacology. While specific characteristics such as its molecular formula, structure, and physical properties may vary, compounds like S39625 are often evaluated for their biological activity, stability, and solubility. Typically, such substances may exhibit properties that make them suitable for use as pharmaceuticals, including potential efficacy against specific biological targets, low toxicity, and favorable pharmacokinetics. The compound may also undergo extensive testing to determine its mechanism of action, therapeutic potential, and safety profile. As with many chemical entities, detailed characterization through techniques such as NMR, mass spectrometry, and chromatography is essential for understanding its behavior in biological systems and its potential applications in drug development. For precise information, including specific properties and applications, consulting scientific literature or databases is recommended.

S39625 is  an E-ring camptothecin keto analogue. S39625 is stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of  S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. Histone gamma-H2AX could be used as a biomarker for the upcoming clinical trials of S39625.

S39625

536711-20-3: S39625, with the CAS number 536711-20-3, is a chemical compound that has garnered interest in various fields, particularly in medicinal chemistry and pharmacology. While specific characteristics such as its molecular formula, structure, and physical properties may vary, compounds like S39625 are often evaluated for their biological activity, stability, and solubility. Typically, such substances may exhibit properties that make them suitable for use as pharmaceuticals, including potential efficacy against specific biological targets, low toxicity, and favorable pharmacokinetics. The compound may also undergo extensive testing to determine its mechanism of action, therapeutic potential, and safety profile. As with many chemical entities, detailed characterization through techniques such as NMR, mass spectrometry, and chromatography is essential for understanding its behavior in biological systems and its potential applications in drug development. For precise information, including specific properties and applications, consulting scientific literature or databases is recommended.

<p>S39625 is a stable, potent topoisomerase I inhibitor with anticancer properties, resistant to efflux transporters, inducing gamma-H2AX at nanomolar levels.</p>

CAS 536711-20-3

S39625

S39625

Ref: TM-T28648