CAS 537049-40-4

Tubacin

Description:

Tubacin, with the CAS number 537049-40-4, is a chemical compound known for its role as a selective inhibitor of the enzyme histone deacetylase 6 (HDAC6). This inhibition is significant in the context of cancer research and neurodegenerative diseases, as HDAC6 is involved in the regulation of protein acetylation, which affects various cellular processes including cell cycle progression and apoptosis. Tubacin is characterized by its ability to enhance the acetylation of α-tubulin, leading to the disruption of microtubule dynamics and promoting the accumulation of misfolded proteins. This compound has been studied for its potential therapeutic applications, particularly in the treatment of multiple myeloma and other malignancies, as well as in models of neurodegenerative disorders. Its selectivity for HDAC6 over other histone deacetylases makes it a valuable tool in research aimed at understanding the role of histone modifications in disease. As with many experimental compounds, further studies are necessary to fully elucidate its pharmacological properties and therapeutic potential.

Formula: C₄₁H₄₃N₃O₇S

InChI: InChI=1/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/s2

InChI key: InChIKey=BHUZLJOUHMBZQY-IDKPYCMBNA-N

SMILES: S(C[C@@H]1O[C@@H](O[C@@H](C1)C2=CC=C(CO)C=C2)C3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)C4=NC(=C(O4)C5=CC=CC=C5)C6=CC=CC=C6

Synonyms:

• Octanediamide, N¹-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N⁸-hydroxy-, rel-
• Tubacin
• rel-N¹-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N⁸-hydroxyoctanediamide
• Octanediamide, N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-, rel-
• Octanediamide, N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N′-hydroxy-, rel-
• rel-N1-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxyoctanediamide

Tubacin

CAS: 537049-40-4

Formula: C₄₁H₄₃N₃O₇S

Purity: 95%

Color and Shape: Solid

Molecular weight: 721.8610

Ref: IN-DA0037O6

Tubacin

CAS: 537049-40-4

Formula: C₄₁H₄₃N₃O₇S

Molecular weight: 721.86

Ref: 7W-GL4943

Tubacin

CAS: 537049-40-4

Tubacin

Purity: ≥95%

Molecular weight: 721.86g/mol

Ref: 54-BUP06752

Tubacin

CAS: 537049-40-4

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.

Formula: C₄₁H₄₃N₃O₇S

Purity: 97.62% - 98.75%

Color and Shape: Solid

Molecular weight: 721.86

Ref: TM-T6327

Tubacin

Controlled Product

CAS: 537049-40-4

Formula: C₄₁H₄₃N₃O₇S

Color and Shape: Neat

Molecular weight: 721.86

Ref: TR-T895513

Tubacin

Controlled Product

CAS: 537049-40-4

Applications Tubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).
References Winkler, R., et al.: Diabetes, 61, 513, (2012);

Formula: C₄₁H₄₃N₃O₇S

Color and Shape: Neat

Molecular weight: 721.86

Ref: TR-T895510

Tubacin

CAS: 537049-40-4

Tubacin is a selective histone deacetylase 6 (HDAC6) inhibitor, which is derived from synthetic chemical sources. It modulates cellular function by inhibiting HDAC6 activity, a key enzyme involved in the deacetylation of α-tubulin. This action leads to an increase in acetylated α-tubulin levels, which has downstream effects on microtubule dynamics and stability. The inhibition of HDAC6 by Tubacin can alter cellular processes such as cell motility, protein degradation, and stress responses, which are important in various physiological and pathological contexts.

Formula: C₄₁H₄₃N₃O₇S

Purity: Min. 95%

Molecular weight: 721.86 g/mol

Ref: 3D-MWA04940