CAS 53760-19-3: Cytochalasin H

Description: Cytochalasin H is a natural product belonging to the cytochalasin family, which are known for their ability to inhibit cell division and affect cytoskeletal dynamics. It is derived from certain fungi, particularly from the genus *Helminthosporium*. The compound is characterized by its complex structure, which includes a lactone ring and multiple functional groups that contribute to its biological activity. Cytochalasin H is primarily recognized for its role as a potent inhibitor of actin polymerization, thereby disrupting the normal function of the cytoskeleton in eukaryotic cells. This disruption can lead to various cellular effects, including altered cell shape, motility, and division. Due to its ability to modulate cellular processes, Cytochalasin H has been utilized in research to study cell biology, particularly in the context of cancer and developmental biology. However, its use is often limited to laboratory settings due to its potent biological effects and potential toxicity. As with many cytochalasins, it is important to handle Cytochalasin H with care, following appropriate safety protocols.

Formula: C₃₀H₃₉NO₅

InChI: InChI=1/C30H39NO5/c1-18-10-9-13-23-27(33)20(3)19(2)26-24(16-22-11-7-6-8-12-22)31-28(34)30(23,26)25(36-21(4)32)14-15-29(5,35)17-18/h6-9,11-15,18-19,23-27,33,35H,3,10,16-17H2,1-2,4-5H3,(H,31,34)/b13-9+,15-14+/t18-,19+,23-,24-,25+,26-,27+,29+,30?/m0/s1

InChI key: InChIKey=NAEWXXDGBKTIMN-OWTACEMYSA-N

SMILES: O=C(OC1C=CC(O)(C)CC(C)CC=CC2C(O)C(=C)C(C)C3C(NC(=O)C123)CC=4C=CC=CC4)C

Synonyms:

• (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindol-1-one
• (3S,3aR,4S,6S,6aR,7E,10S,12S,13E,15R)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1-oxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• 1H-Cycloundec[d]isoindol-1-one, 15-(acetyloxy)-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
• 1H-Cycloundec[d]isoindol-1-one, 15-(acetyloxy)-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, [3S-(3R*,3aS*,4R*,6R*,6aS*,7E,10R*,12S*,13E,15S*,15aS*)]-
• Cytochalasin H
• Cytochalasin O
• Cytochalasin�H from Phomopsis sp.
• Kodocytochalasin 1
• Paspalin P I
• [11]Cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-
• cytochalasin H from A phomopsis species

Cytochalasin H

CAS: 53760-19-3

• Purity: 98.71%
• Molecular weight: 493.63g/mol

Cytochalasin H

CAS: 53760-19-3

• Formula: C₃₀H₃₉NO₅
• Purity: ≥ 98.0%
• Color and Shape: White to off-white solid
• Molecular weight: 493.6

Cytochalasin H

CAS: 53760-19-3

Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) is a potent

• Formula: C₃₀H₃₉NO₅
• Purity: 98.04%
• Color and Shape: Solid
• Molecular weight: 493.63

Cytochalasin H (>90%)

CAS: 53760-19-3

Applications Cytochalasin H is a cell-permeable fungal toxin used in actin polymerization studies and cytological …

• Formula: C₃₀H₃₉NO₅
• Purity: >90%
• Color and Shape: Off-White
• Molecular weight: 493.63

Cytochalasin H

CAS: 53760-19-3

Fungal metabolite; inhibits actin polymerisation

• Formula: C₃₀H₃₉NO₅
• Purity: Min. 95%
• Molecular weight: 493.63 g/mol