CAS 5377-20-8

Metomidate

Description:

Metomidate is a synthetic compound primarily recognized for its use as a short-acting anesthetic agent. It belongs to the class of imidazole derivatives and is characterized by its ability to induce sedation and anesthesia with minimal cardiovascular effects. The molecular structure of metomidate features an imidazole ring, which contributes to its pharmacological properties. It is typically administered intravenously and is known for its rapid onset and relatively short duration of action, making it suitable for procedures requiring brief anesthesia. Metomidate acts primarily as a positive allosteric modulator of the GABA_A receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. This mechanism leads to increased neuronal inhibition, resulting in sedation and anesthesia. While metomidate is effective, it is also associated with certain side effects, including respiratory depression and potential adrenal suppression with prolonged use. Due to its specific pharmacokinetic profile, metomidate is often utilized in both human and veterinary medicine, particularly in situations where rapid recovery from anesthesia is desired.

Formula: C₁₃H₁₄N₂O₂

InChI: InChI=1/C13H14N2O2/c1-10(11-6-4-3-5-7-11)15-9-14-8-12(15)13(16)17-2/h3-10H,1-2H3

InChI key: InChIKey=FHFZEKYDSVTYLL-UHFFFAOYSA-N

SMILES: C(C)(N1C(C(OC)=O)=CN=C1)C2=CC=CC=C2

Synonyms:

• 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, methyl ester
• Aquacalm
• Hypnodil
• Imidazole-5-carboxylic acid, 1-(α-methylbenzyl)-, methyl ester
• Methomidate
• Methoxymol
• Methoxymol R-7315
• Methyl 1-(1-Phenylethyl)Imidazole-5-Carboxylate
• Methyl 1-(α-methylbenzyl)imidazole-5-carboxylate
• R 7315
• methyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
• Metomidate
• 1-(α-Methylbenzyl)iMidazole-5-carboxylic Acid Methyl Ester
• Methyl 3-(1-phenylethyl)imidazole-5-carboxylate
• Methyl 1-[(1RS)-1-phenylethyl]-1H-imidazole-5-carboxylate
• methyl 3-(1-phenylethyl)imidazole-4-carboxylate
• 3-(1-phenylethyl)imidazole-4-carboxylic acid methyl ester
• 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid methyl ester

ETOMIDATE IMPURITY B CRS

CAS: 5377-20-8

ETOMIDATE IMPURITY B CRS

Formula: C₁₃H₁₄N₂O₂

Molecular weight: 230.2625

Ref: 41-E2503004

Etomidate EP Impurity B

CAS: 5377-20-8

Formula: C₁₃H₁₄N₂O₂

Molecular weight: 230.27

Ref: 4Z-E-076061

Metomidate

CAS: 5377-20-8

Applications Metomidate is a the methyl ester analogue of Etomidate (E933300), with sedative and hypnotic properties. Metomidate is mainly used as an anesthetic for veterinary use on its own or in combination with Azaperone (A802200) and other sedatives.
References Mgasa, M.N. et al.: J. Vet. Med. Ser. A, 36, 225 (1989); Roztocil, V. et al.: Acta Vet. Brno, 41, 339 (1972); Mattson, N.S. et al.: Aquaculture, 83, 89 (1989);

Formula: C₁₃H₁₄N₂O₂

Color and Shape: Neat

Molecular weight: 230.26

Ref: TR-M338755

Etomidate EP Imourity B

CAS: 5377-20-8

Formula: C₁₃H₁₄N₂O₂

Molecular weight: 230.3

Ref: ST-EA-CP-E41002