CAS 53772-84-2

trans-Clopenthixol

Description:

Trans-Clopenthixol is an antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It belongs to the thioxanthene class of compounds and is characterized by its ability to antagonize dopamine receptors, particularly the D2 subtype, which plays a crucial role in its therapeutic effects. The substance exhibits a high affinity for serotonin receptors as well, contributing to its efficacy in managing symptoms. Trans-Clopenthixol is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. The compound is known for its sedative properties and can also influence other neurotransmitter systems, including adrenergic and histaminergic pathways. Its pharmacokinetics involve extensive hepatic metabolism, and it is primarily excreted through urine. Common side effects may include sedation, extrapyramidal symptoms, and weight gain, necessitating careful monitoring during treatment. Overall, trans-Clopenthixol is a significant agent in psychiatric medicine, providing relief for individuals suffering from severe mental health conditions.

Formula: C₂₂H₂₅ClN₂OS

InChI: InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5+

InChI key: InChIKey=WFPIAZLQTJBIFN-BLLMUTORSA-N

SMILES: C(\CCN1CCN(CCO)CC1)=C\2/C=3C(SC=4C2=CC=CC4)=CC=C(Cl)C3

Synonyms:

• (E)-Clopenthixol
• 1-Piperazineethanol, 4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-, (E)-
• 1-piperazineethanol, 4-[(3E)-3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-
• 4-[(3E)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol
• 9H-Thioxanthene, 1-piperazineethanol deriv.
• trans-Clopenthixol
• β-Clopenthixol
• 2-{4-[(3E)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]piperazin-1-yl}ethanol

trans-Clopenthixol-d4 (-)-10-Camphorsulfonic Acid Salt

Controlled Product

CAS: 53772-84-2

Applications The trans isomer of Clopenthixol, which exhibits similar pharmacological properties with its cis-isomer, Zuclopenthixol, less anti-dopaminergic effects.
References Leysen, J., et al.: Psychopharmacol., 110, 27 (1993), Pajeva, I., et al.: J. Med. Chem., 41, 1815 (1998), Varga, A., et al.: Anticancer Res., 21, 2709 (2001),

Formula: C₂₂D₄H₂₁ClN₂OS·C₁₀H₁₆O₄S

Color and Shape: Neat

Molecular weight: 637.286

Ref: TR-C587192

trans-Clopenthixol

CAS: 53772-84-2

Trans-Clopenthixol ((E)-Clopenthixol) is an antibiotic without any sedative properties. It can be used in vitro to inhibit Pseudomonas aeruginosa and Plasmodium falciparum.

Formula: C₂₂H₂₅ClN₂OS

Color and Shape: Solid

Molecular weight: 400.965

Ref: TM-T206127