CAS 53774-63-3

H-Lys(acetimidoyl)-OH

Description:

H-Lys(acetimidoyl)-OH, also known by its CAS number 53774-63-3, is a derivative of the amino acid lysine, characterized by the presence of an acetimidoyl group attached to the lysine side chain. This modification can influence the compound's reactivity and biological activity. The substance typically exhibits properties associated with amino acids, such as solubility in water due to the presence of polar functional groups. The acetimidoyl modification may enhance its ability to participate in various chemical reactions, including peptide bond formation and interactions with biological macromolecules. Additionally, the compound may play a role in biochemical pathways or serve as a building block in the synthesis of peptides and proteins. Its specific applications can vary, but it is often utilized in research settings, particularly in studies involving protein engineering or drug development. As with many chemical substances, safety data sheets should be consulted for handling and storage guidelines to ensure safe use in laboratory environments.

Formula: C₈H₁₇N₃O₂

Synonyms:

• N-(5-Amino-5-Carboxypentyl)-Acetamidine

H-Lys(acetimidoyl)-OH

CAS: 53774-63-3

L-NIL inhibited mouse inducible nitric oxide synthase with an IC₅₀ of 3.3 µM compared to an IC₅₀ of 92 µM obtained for rat brain constitutive NOS. The lysine-derived inhibitor may be useful as a selective and potent inhibitor of inducible NOS for determining the role of this enzyme in disease models (e.g. chronic inflammation and autoimmune diseases). Bryk et al. studied the suicidal disactivation of neuronal NOS by L-NIL.

Formula: C₈H₁₇N₃O₂

Purity: ≥ 99%

Color and Shape: White Powder

Molecular weight: 187.24

Ref: 01-4026182

N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE

CAS: 53774-63-3

Formula: C₈H₁₇N₃O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 187.2395

Ref: IN-DA00DAXP

L-NIL

CAS: 53774-63-3

L-NIL inhibits inducible NO synthase (mouse) with an IC50 of 3.3 μM and blocks rat brain NO synthase (IC50: 92 μM).

Formula: C₈H₁₇N₃O₂

Purity: 99.2%

Color and Shape: Solid

Molecular weight: 187.24

Ref: TM-T11805

H-Lys(acetimidoyl)-OH

CAS: 53774-63-3

Lysine acetimidate is a reactive compound that can be activated by the addition of an acid. Lysine acetimidate is a potent activator of macrophages and other inflammatory cells. It has been used in experimental models to study bowel disease and repair mechanisms. In these models, lysine acetimidate has shown to have anti-inflammatory effects, which may be due to its ability to decrease the production of pro-inflammatory cytokines by immune cells. The metabolic disorder caused by lysine acetimidate is still being studied. Lysine acetimidate also has immunomodulatory effects, as it can inhibit the synthesis of epidermal growth factor (EGF) in lung cells and cause damage to alveolar type II cells in the lung.

Formula: C₈H₁₇N₃O₂

Purity: Min. 95%

Molecular weight: 187.24 g/mol

Ref: 3D-FL107911