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CAS 53861-42-0

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Cis-diammineaquachloroplatinum(1+)

Description:
Cis-diammineaquachloroplatinum(1+) is a coordination complex of platinum, commonly referred to as cisplatin. It features a platinum(II) center coordinated to two ammonia (NH3) ligands, one water (H2O) molecule, and one chloride (Cl-) ion. This compound is characterized by its square planar geometry, which is typical for platinum(II) complexes. The "cis" designation indicates that the ammonia ligands are positioned adjacent to each other, influencing the compound's biological activity. Cisplatin is well-known for its use in chemotherapy, particularly in the treatment of various cancers, including testicular, ovarian, and bladder cancers. Its mechanism of action involves the formation of DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cell death. The compound is typically administered intravenously and can have side effects, including nephrotoxicity and nausea. Due to its significant therapeutic effects, cis-diammineaquachloroplatinum(1+) remains a critical agent in oncological pharmacotherapy.
Formula:ClH8N2OPt
InChI:InChI=1S/ClH.2H3N.H2O.Pt/h1H;2*1H3;1H2;/q;;;;+2/p-1
InChI key:InChIKey=ABAUMWKZAPJXJX-UHFFFAOYSA-M
SMILES:[Pt+2]([Cl-])([NH3])([NH3])[OH2]
Synonyms:
  • Platinum(1+), diammineaquachloro-, (SP-4-3)-
  • Cis-diammineaquachloroplatinum(1+)
  • cis-Diammineaquachloroplatinum(1+)
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