CAS 53866-34-5

Estrone-2,4,16,16-d4

Description:

Estrone-2,4,16,16-d4 is a deuterated form of estrone, a naturally occurring estrogen steroid hormone. The "d4" designation indicates that four hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which is often used in research to trace metabolic pathways or in pharmacokinetic studies. Estrone itself is a key hormone in the regulation of the menstrual cycle and is involved in various physiological processes, including the development of secondary sexual characteristics. The presence of deuterium can alter the compound's physical and chemical properties, such as its stability and solubility, compared to its non-deuterated counterpart. Estrone-2,4,16,16-d4 is primarily utilized in scientific research, particularly in studies related to hormone metabolism and the effects of estrogens in biological systems. Its CAS number, 53866-34-5, is a unique identifier that facilitates the cataloging and identification of this specific chemical substance in databases and regulatory documents.

Formula: C₁₈H₁₈D₄O₂

InChI: InChI=1/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1/i3D,7D2,10D

Synonyms:

• 3-hydroxy(2,4,16,16-2H4)estra-1,3,5(10)-trien-17-one

Estrone-d4 (Estriol EP Impurity B-d4)

CAS: 53866-34-5

Formula: C₁₈H₁₈D₄O₂

Color and Shape: White To Off-White Solid

Molecular weight: 274.40

Ref: 4Z-E-111

Estrone-2,4,16,16-d4

CAS: 53866-34-5

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 274.39

Ref: 3U-D3650

Estrone D4 (2,4,16,16-D4) 100 µg/mL in Acetonitrile

Controlled Product

CAS: 53866-34-5

Formula: C₁₈D₄H₁₈O₂

Color and Shape: Single Solution

Molecular weight: 274.39

Ref: 04-A13213235AL-100

Estrone D4 (2,4,16,16-D4)

Controlled Product

CAS: 53866-34-5

Formula: C₁₈D₄H₁₈O₂

Color and Shape: Neat

Molecular weight: 274.39

Ref: 04-C13213235

Estrone-2,4,16,16-d4

CAS: 53866-34-5

Formula: C₁₈H₁₈D₄O₂

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 274.39

Ref: 7W-GC2791

Estrone-d4

Controlled Product

CAS: 53866-34-5

Applications Isotope labelled Estrone (E889050), which is a metabolite of 17β-Estradiol (E888000). During the metabolism, it is in rapid equilibrium with Estriol (E888960) and 17β-Estradiol (E888000) (1). Causes the feminization of male fish at human and animal waste sites (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Both, D. et al.: Anal. Prof. Drug Subst. 1983 12 pp135-1892. Goodman-Gruen, D. et al.: J. Clin. Endocrinol. Metab. 1996 Aug;81(8):2999-3003.

Formula: C₁₈D₄H₁₈O₂

Color and Shape: White Solid

Molecular weight: 274.39

Ref: TR-E889052

Estrone-2,4,16,16-d4

Controlled Product

CAS: 53866-34-5

Estrone-2,4,16,16-d4 is a synthetic estrogen that is used in the treatment of prostate cancer and breast cancer. It has been validated by LC-MS/MS methods to detect estrone-2,4,16,16-d4 in urine samples. The linear regression analysis was performed on the data obtained from the validation study. Results show that estrone-2,4,16,16-d4 can be reliably detected in wastewater effluents at concentrations as low as 1 ng/L. Industrial chemicals such as phthalates and polycyclic aromatic hydrocarbons are found to have a significant correlation with urinary levels of estradiol and its conjugates. This product may also be measured in maternal serum or muscle tissue with an on-line analyzer.

Formula: C₁₈D₄H₁₈O₂

Purity: Min. 95%

Molecular weight: 274.39 g/mol

Ref: 3D-DCA86634

ESTRONE-2,4,16,16-D4

CAS: 53866-34-5

Formula: C₁₈H₁₈D₄O₂

Color and Shape: Solid

Molecular weight: 274.3907

Ref: IN-DA00DAMN