CAS 539-03-7

N-(4-Chlorophenyl)acetamide

Description:

N-(4-Chlorophenyl)acetamide, also known as 4-Chloroacetanilide, is an organic compound characterized by its amide functional group attached to a chlorinated aromatic ring. It appears as a white to off-white crystalline solid and is soluble in organic solvents such as ethanol and acetone, but has limited solubility in water. The presence of the 4-chlorophenyl group contributes to its chemical stability and influences its reactivity, making it a useful intermediate in organic synthesis. This compound is often utilized in the production of pharmaceuticals, agrochemicals, and dyes. Its melting point and boiling point can vary based on purity and environmental conditions. Additionally, N-(4-Chlorophenyl)acetamide exhibits moderate toxicity, necessitating careful handling and adherence to safety protocols during its use in laboratory and industrial settings. As with many amides, it can participate in various chemical reactions, including hydrolysis and acylation, making it a versatile building block in synthetic chemistry.

Formula: C₈H₈ClNO

InChI: InChI=1S/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11)

InChI key: InChIKey=GGUOCFNAWIODMF-UHFFFAOYSA-N

SMILES: N(C(C)=O)C1=CC=C(Cl)C=C1

Synonyms:

• 2-(4-Chlorophenyl)Acetamide
• Acetamide, N-(4-chlorophenyl)-
• Acetanilide, 4′-chloro-
• N-(4-Chlorophenyl)acetamide
• N-(4-Chlorophenyl)ethaneamide
• N-(p-Chlorophenyl)acetamide
• N-Acetyl-4-chloroaniline
• N-Acetyl-p-chloroaniline
• NSC 40563
• NSC 444
• p-Chloroacetanilide
• 4-Chloroacetanilide

4'-Chloroacetanilide

CAS: 539-03-7

Formula: C₈H₈ClNO

Purity: >98.0%(GC)(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 169.61

Ref: 3B-C0089

4'-Chloroacetanilide, 98+%

CAS: 539-03-7

4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand

Formula: C₈H₈ClNO

Purity: 98+%

Color and Shape: White to cream to pale brown or grey, Crystals or powder or crystalline powder

Molecular weight: 169.61

Ref: 02-A11214

PARACETAMOL IMPURITY J CRS

CAS: 539-03-7

PARACETAMOL IMPURITY J CRS

Ref: 41-Y0001945

Acetaminophen Related Compound J (N-(4-chlorophenyl)acetamide)

CAS: 539-03-7

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₈H₈ClNO

Color and Shape: White Light Yellow Brown Crystalline Powder

Molecular weight: 169.61 g/mol

Ref: 45-1003100

p-Chloroacetanilide

CAS: 539-03-7

Formula: C₈H₈ClNO

Purity: 97%

Color and Shape: Solid

Molecular weight: 169.6082

Ref: IN-DA003L68

4'-Chloroacetanilide

CAS: 539-03-7

4'-Chloroacetanilide

Formula: C₈H₈ClNO

Purity: ≥95%

Color and Shape: off-white solid

Molecular weight: 169.61g/mol

Ref: 54-OR4345

4'-Chloroacetanilide, min. 98%

CAS: 539-03-7

Formula: C₈H₈ClNO

Purity: min. 98%

Color and Shape: White to off-white solid

Molecular weight: 169.61

Ref: 08-07-0135

Paracetamol (Acetaminophen) EP Impurity J (Acetaminophen USP Related Compound J)

CAS: 539-03-7

Formula: C₈H₈ClNO

Color and Shape: White To Off-White Solid

Molecular weight: 169.61

Ref: 4Z-A-0213

Paracetamol EP Impurity J (Acetaminophen USP Related Compound J)

Controlled Product

CAS: 539-03-7

Formula: C₈H₈ClNO

Color and Shape: Neat

Molecular weight: 169.61

Ref: 86-MM0042.02

4-Chloroacetanilide

CAS: 539-03-7

Formula: C₈H₈ClNO

Color and Shape: Neat

Molecular weight: 169.61

Ref: 04-C11348000

4'-Chloroacetanilide

Controlled Product

CAS: 539-03-7

Applications 4′-Chloroacetanilide is an impurity of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3,4).
References (1) Călinescu, O., et al.: J. Chromatogr. Sci. 50(4), 335-42, (2012)(2) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (4) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Formula: C₈H₈ClNO

Color and Shape: Neat

Molecular weight: 169.61

Ref: TR-C363355

Acetaminophen EP Impurity J

CAS: 539-03-7

Formula: C₈H₈ClNO

Molecular weight: 169.61

Ref: ST-EA-CP-A7031

Paracetamol EP Impurity J

CAS: 539-03-7

Formula: C₈H₈ClNO

Molecular weight: 169.61

Ref: ST-EA-CP-P10010

4'-Chloroacetanilide

CAS: 539-03-7

4'-Chloroacetanilide is a white, crystalline solid. It is soluble in water and has low solubility in organic solvents such as benzene, toluene, and chloroform. It also exhibits low volatility and a melting point of 148-150 degrees Celsius. 4'-Chloroacetanilide can be prepared by the reaction of acetanilide with sodium hypochlorite in the presence of an acid catalyst. The compound has been shown to have acute toxicities and hydrogen bonding interactions with proteins. The compound's biochemical properties include its ability to inhibit bacterial growth, which may be due to its inhibition of protein synthesis. 4'-Chloroacetanilide is used as a pharmaceutical preparation for the treatment of parasitic infections that are resistant to other drugs.

Formula: C₈H₈ClNO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 169.61 g/mol

Ref: 3D-FC20179

p-Chloroacetanilide extrapure AR, 99%

CAS: 539-03-7

Formula: C₈H₈NOCl

Purity: min. 99.0%

Color and Shape: White to Off white, Crystalline powder, Clear

Molecular weight: 169.61

Ref: SR-37281

p-Chloroacetanilide extrapure AR, ExiPlus, Multi-Compendial, 99%

CAS: 539-03-7

Formula: C₈H₈NOCl

Purity: min. 99%

Color and Shape: White to off-white, Crystalline powder, Clear

Molecular weight: 169.61

Ref: SR-77863

N-(4-chlorophenyl)acetamide

CAS: 539-03-7

Formula: C₈H₈ClNO

Purity: 95%

Molecular weight: 169.61

Ref: 10-F358429