CAS 539-03-7
:N-(4-Chlorophenyl)acetamide
Description:
N-(4-Chlorophenyl)acetamide, also known as 4-Chloroacetanilide, is an organic compound characterized by its amide functional group attached to a chlorinated aromatic ring. It appears as a white to off-white crystalline solid and is soluble in organic solvents such as ethanol and acetone, but has limited solubility in water. The presence of the 4-chlorophenyl group contributes to its chemical stability and influences its reactivity, making it a useful intermediate in organic synthesis. This compound is often utilized in the production of pharmaceuticals, agrochemicals, and dyes. Its melting point and boiling point can vary based on purity and environmental conditions. Additionally, N-(4-Chlorophenyl)acetamide exhibits moderate toxicity, necessitating careful handling and adherence to safety protocols during its use in laboratory and industrial settings. As with many amides, it can participate in various chemical reactions, including hydrolysis and acylation, making it a versatile building block in synthetic chemistry.
Formula:C8H8ClNO
InChI:InChI=1S/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11)
InChI key:InChIKey=GGUOCFNAWIODMF-UHFFFAOYSA-N
SMILES:N(C(C)=O)C1=CC=C(Cl)C=C1
Synonyms:- 2-(4-Chlorophenyl)Acetamide
- Acetamide, N-(4-chlorophenyl)-
- Acetanilide, 4′-chloro-
- N-(4-Chlorophenyl)acetamide
- N-(4-Chlorophenyl)ethaneamide
- N-(p-Chlorophenyl)acetamide
- N-Acetyl-4-chloroaniline
- N-Acetyl-p-chloroaniline
- NSC 40563
- NSC 444
- p-Chloroacetanilide
- 4-Chloroacetanilide
- See more synonyms
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4'-Chloroacetanilide
CAS:Formula:C8H8ClNOPurity:>98.0%(GC)(N)Color and Shape:White to Light yellow powder to crystalMolecular weight:169.614'-Chloroacetanilide, 98+%
CAS:4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brandFormula:C8H8ClNOPurity:98+%Color and Shape:White to cream to pale brown or grey, Crystals or powder or crystalline powderMolecular weight:169.61Acetaminophen Related Compound J
CAS:Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof, nesoiFormula:C8H8ClNOColor and Shape:White Light Yellow Brown Crystalline PowderMolecular weight:169.61 g/mol4'-Chloroacetanilide
CAS:4'-ChloroacetanilideFormula:C8H8ClNOPurity:≥95%Color and Shape:Pale yellow Solid-PowderMolecular weight:169.60822Paracetamol EP Impurity J (Acetaminophen USP Related Compound J)
CAS:Formula:C8H8ClNOColor and Shape:White To Off-White SolidMolecular weight:169.61Paracetamol EP Impurity J (Acetaminophen USP Related Compound J)
CAS:Controlled ProductFormula:C8H8ClNOColor and Shape:NeatMolecular weight:169.614'-Chloroacetanilide
CAS:Controlled ProductApplications 4′-Chloroacetanilide is an impurity of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3,4).
References (1) Călinescu, O., et al.: J. Chromatogr. Sci. 50(4), 335-42, (2012)(2) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (4) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)Formula:C8H8ClNOColor and Shape:NeatMolecular weight:169.61Paracetamol impurity J
CAS:N-(4-Chlorophenyl)acetamideFormula:C8H8ClNOPurity:98%Molecular weight:169.614'-Chloroacetanilide
CAS:4'-Chloroacetanilide is a white, crystalline solid. It is soluble in water and has low solubility in organic solvents such as benzene, toluene, and chloroform. It also exhibits low volatility and a melting point of 148-150 degrees Celsius. 4'-Chloroacetanilide can be prepared by the reaction of acetanilide with sodium hypochlorite in the presence of an acid catalyst. The compound has been shown to have acute toxicities and hydrogen bonding interactions with proteins. The compound's biochemical properties include its ability to inhibit bacterial growth, which may be due to its inhibition of protein synthesis. 4'-Chloroacetanilide is used as a pharmaceutical preparation for the treatment of parasitic infections that are resistant to other drugs.Formula:C8H8ClNOPurity:Min. 95%Color and Shape:PowderMolecular weight:169.61 g/mol4'-Chloroacetanilide, min. 98%
CAS:Formula:C8H8ClNOPurity:min. 98%Color and Shape:White to off-white solidMolecular weight:169.61p-Chloroacetanilide Reagent Grade, 95%
CAS:Formula:C8H8NOClPurity:min. 95.0%Color and Shape:White to off-white, Crystalline powder, ClearMolecular weight:169.61p-Chloroacetanilide ExiPlus, Multi-Compendial, 95%
CAS:Formula:C8H8NOClPurity:min. 95.0%Color and Shape:White to Pale yellow, Crystalline powder or Needle shaped crystals, ClearMolecular weight:169.61
