CAS 53902-12-8

tranilast

Description:

Tranilast is a chemical compound known for its anti-allergic and anti-inflammatory properties. It is classified as a non-steroidal agent and is primarily used in the treatment of allergic conditions, such as asthma and allergic rhinitis, as well as in dermatological applications for conditions like keloids and hypertrophic scars. The molecular structure of tranilast features a benzamide core, which contributes to its biological activity. It acts by inhibiting the release of mediators from mast cells and has been shown to modulate various inflammatory pathways. Tranilast is also noted for its potential in the treatment of certain cancers and fibrotic diseases due to its ability to inhibit collagen synthesis. The compound is generally well-tolerated, with a favorable safety profile, although side effects can occur. Its solubility characteristics and pharmacokinetics make it suitable for oral administration. Overall, tranilast represents a versatile therapeutic agent with a range of applications in managing allergic and inflammatory conditions.

Formula: C₁₈H₁₇NO₅

InChI: InChI=1/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+

InChI key: InChIKey=NZHGWWWHIYHZNX-UHFFFAOYSA-N

SMILES: N(C(C=CC1=CC(OC)=C(OC)C=C1)=O)C2=C(C(O)=O)C=CC=C2

Synonyms:

• 2-(3,4-Dimethoxycinnamoylamino)benzoic acid
• 2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid
• 2-[3-(3,4-Dimethoxyphenyl)prop-2-enoylamino]benzoic acid
• 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]benzoic acid
• 2-{[(2E)-3-(3,4-Dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
• 3,4-Daa
• Benzoic acid, 2-[[(2E)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-
• Benzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-
• Benzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]-
• Mk 341
• N-(3,4-Dimethoxycinnamoyl)anthranilic acid
• Rizaben
• Tranpro
• benzoic acid, 2-[[(2E)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]-
• N 5′
• Anthranilic acid, N-(3,4-dimethoxycinnamoyl)-
• 2-[[3-(3,4-DIMETHOXYPHENYL)-1-OXO-2-PROPENYL]AMINO] BENZOIC ACID
• 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)-benzoicaci
• N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID
• SB-252218
• TRANILAST
• n-(3,4-dimethoxycinnamoyl)-anthranilicaci

Tranilast

CAS: 53902-12-8

Formula: C₁₈H₁₇NO₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Green powder to crystal

Molecular weight: 327.34

Ref: 3B-T2935

TRANILAST

CAS: 53902-12-8

Formula: C₁₈H₁₇NO₅

Purity: 96%

Color and Shape: Solid

Molecular weight: 327.3313

Ref: IN-DA003UUF

Tranilast

CAS: 53902-12-8

Tranilast

Purity: 98%

Molecular weight: 327.33g/mol

Ref: 54-OR1030246

Tranilast

CAS: 53902-12-8

Tranilast

Purity: ≥98%

Molecular weight: 327.33g/mol

Ref: 54-BUP17791

Tranilast

CAS: 53902-12-8

Formula: C₁₈H₁₇NO₅

Molecular weight: 327.34

Ref: 4Z-T-223001

Tranilast

CAS: 53902-12-8

Formula: C₁₈H₁₇NO₅

Purity: ≥ 98.0%

Color and Shape: White to beige powder

Molecular weight: 327.33

Ref: 7W-GP8731

Tranilast

CAS: 53902-12-8

Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of

Formula: C₁₈H₁₇NO₅

Purity: 99.67% - >99.99%

Color and Shape: White With Light Yellow Crystalline Powder

Molecular weight: 327.33

Ref: TM-T2690

Tranilast-D₆

Controlled Product

CAS: 53902-12-8

Applications Tranilast-d6 is the isotope labelled analogue of Tranilast (T714570), a antiallergic drug used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
References Shiota, N., et al.: Brit. J. Pharmacol., 159, 626 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Kawabata, Y., et al.: Eur. J. Pharm. Sci., 39, 256 (2010),

Formula: C₁₈H₁₁D₆NO₅

Color and Shape: Neat

Molecular weight: 333.37

Ref: TR-T714577

Tranilast

Controlled Product

CAS: 53902-12-8

Applications Antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
References Shiota, N., et al.: Brit. J. Pharmacol., 159, 626 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Kawabata, Y., et al.: Eur. J. Pharm. Sci., 39, 256 (2010),

Formula: C₁₈H₁₇NO₅

Color and Shape: Neat

Molecular weight: 327.33

Ref: TR-T714570

Tranilast - Bio-X ™

CAS: 53902-12-8

Tranilast is an anti-allergic drug that is used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It inhibits the release of histamine from mast cells and basophils. Tranilast has been shown to inhibit the production and release of various proinflammatory cytokines, such as interleukins (IL-1, IL-6) and tumor necrosis factor-alpha (TNF-alpha) and by inhibiting their activity, this drug helps to suppress the inflammatory response.

Formula: C₁₈H₁₇NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 327.33 g/mol

Ref: 3D-BD164491

Tranilast

CAS: 53902-12-8

Inhibits VEGF-induced angiogenesis; anti-asthma drug; anti-proliferative

Formula: C₁₈H₁₇NO₅

Purity: Min. 95%

Color and Shape: Yellow Green Powder

Molecular weight: 327.33 g/mol

Ref: 3D-FD28369

Tranilast

CAS: 53902-12-8

M02569 - Tranilast

Formula: C₁₈H₁₇NO₅

Purity: >98%

Color and Shape: Solid

Molecular weight: 327.336

Ref: 10-M02569