CAS 53917-42-3

adrenocorticotropic hormone fragment*18-39 human

Description:

Adrenocorticotropic hormone fragment 18-39 (ACTH 18-39) is a peptide derived from the larger adrenocorticotropic hormone (ACTH), which plays a crucial role in the regulation of cortisol production from the adrenal glands. This specific fragment consists of amino acids 18 to 39 of the full ACTH sequence, retaining some of the biological activity associated with the parent hormone. It is characterized by its role in stimulating the adrenal cortex and influencing various physiological processes, including stress response and metabolism. The CAS number 53917-42-3 uniquely identifies this peptide in chemical databases, facilitating its study and application in research and therapeutic contexts. ACTH 18-39 is often utilized in scientific research to explore its effects on adrenal function and its potential implications in disorders related to adrenal insufficiency or dysregulation. As a peptide, it exhibits properties typical of proteins, such as solubility in aqueous solutions and susceptibility to enzymatic degradation, which are important considerations in its handling and application.

Formula: C₁₁₂H₁₆₅N₂₇O₃₆

InChI: InChI=1/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)

SMILES: CC(C)CC(C(=NC(CCC(=O)O)C(=NC(Cc1ccccc1)C(=O)O)O)O)N=C(C1CCCN1C(=O)C(Cc1ccccc1)N=C(C(C)N=C(C(CCC(=O)O)N=C(C(C)N=C(C(CO)N=C(C(CCC(=O)O)N=C(C(CC(=O)O)N=C(C(CCC(=O)O)N=C(C(C)N=C(CN=C(C(CC(=N)O)N=C(C1CCCN1C(=O)C(Cc1ccc(cc1)O)N=C(C(C(C)C)N=C(C(CCCCN)N=C(C(C(C)C)N=C(C1CCCN1C(=O)C(CCCNC(=N)N)N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

Synonyms:

• ACTH (18-39) (human)
• H-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH
• Arginylprolylvalyllysylvalyltyrosylprolylasparaginylglycylalanyl-Α-Glutamyl-Α-Aspartyl-Α-Glutamylserylalanyl-Α-Glutamylalanylphenylalanylprolylleucyl-Α-Glutamylphenylalanine
• Clip

ACTH (18-39) (human)

CAS: 53917-42-3

Corticotropin-like intermediate lobe peptide (CLIP). CLIP is generated as a proteolytic cleavage product of adrenocorticotropic hormone (ACTH).

Formula: C₁₁₂H₁₆₅N₂₇O₃₆

Purity: 92.3%

Color and Shape: White Powder

Molecular weight: 2465.7

Ref: 01-4008985

CLIP

CAS: 53917-42-3

Formula: C₁₁₂H₁₆₅N₂₇O₃₆

Purity: 95%

Molecular weight: 2465.6678

Ref: IN-DA00D88H

Adrenocorticotropic Hormone (ACTH) (18-39), human

CAS: 53917-42-3

ACTH (18-39), or Corticotropin-like Peptide, boosts insulin, amylase, and protein secretion dose-dependently.

Formula: C₁₁₂H₁₆₅N₂₇O₃₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 2465.67

Ref: TM-TP1241

ACTH (18-39) (human)

CAS: 53917-42-3

ACTH is a polypeptide hormone that regulates the release of cortisol from the adrenal cortex. ACTH (18-39) is a fragment of ACTH which binds to the glucocorticoid receptor with high affinity. The carboxy terminal sequence of ACTH (18-39) is identical to that of human ACTH and can be used as an immunogen to produce monoclonal antibodies against ACTH. The monoclonal antibodies can then be used in prognostic studies for patients with congestive heart failure, diabetic neuropathy, or k562 cells. ACTH (18-39) has an optimum pH level of 7.0 and can bind to cellular receptors at physiological concentrations. It also has a molecular weight of 4,000 Daltons and is soluble in trifluoroacetic acid and hydrogen fluoride, but not in water or methanol.

Formula: C₁₁₂H₁₆₅N₂₇O₃₆

Purity: Min. 95%

Molecular weight: 2,465.67 g/mol

Ref: 3D-FA108384

Human ACTH(18-39) trifluoroacetate

CAS: 53917-42-3

Please enquire for more information about Human ACTH(18-39) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₁₂H₁₆₅N₂₇O₃₆•(C₂HF₃O₂)x

Ref: 3D-BH183880