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CAS 53933-60-1

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trans-Sulindac

Description:
Trans-Sulindac is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is a derivative of sulindac, which is a prodrug that is converted in the body to its active form. The chemical structure of trans-Sulindac features a sulfinyl group, which contributes to its pharmacological activity. It is characterized by its ability to inhibit cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. Trans-Sulindac is often utilized in the management of conditions such as arthritis and other inflammatory disorders. Its pharmacokinetics include oral bioavailability, with metabolism primarily occurring in the liver. The compound is known for its relatively favorable safety profile compared to other NSAIDs, although it can still cause gastrointestinal and cardiovascular side effects. As with any medication, it is important to use trans-Sulindac under medical supervision to monitor for potential adverse effects and interactions with other drugs.
Formula:C20H17FO3S
InChI:InChI=1/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+
InChI key:InChIKey=MLKXDPUZXIRXEP-RQZCQDPDNA-N
SMILES:C(=C\1/C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3
Synonyms:
  • (1E)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
  • (E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
  • 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (E)-
  • 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1E)-
  • 2-(6-Fluoro-2-methyl-3-((4-methylsulfinylphenyl)methylidene)inden-1-yl)acetic acid
  • trans-Sulindac
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