CAS 53948-46-2

3-(carbamoylhydrazono)propyl N,N-bis(2-chloroethyl)diamidophosphate

Description:

3-(Carbamoylhydrazono)propyl N,N-bis(2-chloroethyl)diamidophosphate, with the CAS number 53948-46-2, is a chemical compound that belongs to the class of organophosphorus compounds. It features a phosphorus atom bonded to two chloroethyl groups and a propyl chain that is substituted with a carbamoylhydrazone functional group. This compound is characterized by its potential use in various applications, including as a pesticide or herbicide, due to the presence of the phosphorus moiety, which is known for its biological activity. The chloroethyl groups contribute to its reactivity and may enhance its ability to interact with biological targets. Additionally, the hydrazone linkage can impart specific chemical properties, such as stability and reactivity under certain conditions. As with many organophosphorus compounds, safety considerations are paramount, as they may exhibit toxicity to non-target organisms. Proper handling and usage guidelines are essential to mitigate any potential risks associated with this compound.

Formula: C₈H₁₈Cl₂N₅O₃P

InChI: InChI=1/C8H18Cl2N5O3P/c9-2-5-15(6-3-10)19(12,17)18-7-1-4-13-14-8(11)16/h4H,1-3,5-7H2,(H2,12,17)(H3,11,14,16)

SMILES: C(C=NNC(=N)O)COP(=O)(N)N(CCCl)CCCl

Hydroxy Cyclophosphamide Semicarbazone (80%)

Controlled Product

CAS: 53948-46-2

Applications Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
References Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947); Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962); Fraiser, L.H., et al.: Drugs, 42, 781 (1991); Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999);

Formula: C₈H₁₈Cl₂N₅O₃P

Purity: 80%

Color and Shape: Neat

Molecular weight: 334.14

Ref: TR-H926305

Hydroxy Cyclophosphamide Semicarbazone-d4 (>80%)

Controlled Product

CAS: 53948-46-2

Stability Hygroscopic
Applications Isotope labelled Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
References Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947); Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),

Formula: C₈H₁₄D₄Cl₂N₅O₃P

Purity: >80%

Color and Shape: Neat

Molecular weight: 338.16

Ref: TR-H926307

Hydroxy cyclophosphamide semicarbazone-d4

CAS: 53948-46-2

Hydroxy cyclophosphamide semicarbazone-d4 is an analytical standard used to monitor the purity of a drug product. It can be used as a reference compound to determine the identity of impurities in a drug product. Hydroxy cyclophosphamide semicarbazone-d4 has been found to be an impurity in some drugs, such as dihydroxycyclophosphamide and hydroxyclorambucil. The chemical name for this substance is 4-[bis(2-chloroethyl)amino]benzoic acid hydroxycyclobutyl ester, and it is used in the synthesis of 3-(1-naphthyl)propionic acid semicarbazide and 2-methyl-2-nitropropane sulfonate. Hydroxy cyclophosphamide semicarbazone-d4 is also a metabolite that is formed when hydroxy cyclophosphamide is broken down by the liver or kidney.

Formula: C₈H₁₈Cl₂N₅O₃P

Purity: Min. 95%

Molecular weight: 334.14 g/mol

Ref: 3D-DCA94846