CAS 54-05-7

Chloroquine

Description:

Chloroquine is a synthetic compound primarily known for its use as an antimalarial drug. It belongs to the class of 4-aminoquinolines and is characterized by its ability to interfere with the growth of parasites in red blood cells. The chemical formula of chloroquine is C18H26ClN3, and it has a molecular weight of approximately 319.87 g/mol. Chloroquine is typically presented as a white to off-white crystalline powder that is soluble in water and exhibits a bitter taste. Its mechanism of action involves the inhibition of heme polymerization within the malaria parasite, leading to toxic accumulation of heme. In addition to its antimalarial properties, chloroquine has also been investigated for potential antiviral effects and as an anti-inflammatory agent in conditions like rheumatoid arthritis and lupus. However, its use has been associated with various side effects, including gastrointestinal disturbances and retinal toxicity with long-term use. Due to the emergence of drug-resistant malaria strains, chloroquine's efficacy has diminished in some regions, prompting the exploration of alternative treatments.

Formula: C₁₈H₂₆ClN₃

InChI: InChI=1/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)/t14-/m0/s1

InChI key: InChIKey=WHTVZRBIWZFKQO-UHFFFAOYSA-N

SMILES: N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Synonyms:

• (4S)-N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine
• 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-
• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹,N¹-diethyl-
• 4-(7-Chloro-4-Quinolylamino)Pentyldiethylamine
• 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
• Aralen
• Artrichin
• Bipiquin
• Capquin
• Chloraquine
• Chloro Quine Phosphate
• Chlorochin
• Chlorolex
• Chloroquin
• Cloquin
• Cloroquina
• E-Vivax
• Maliago
• N⁴-(7-Chloro-4-quinolinyl)-N¹,N¹-diethyl-1,4-pentanediamine
• Nivaquinp
• Nsc 187208
• Premoquine
• Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-
• Reumachlor
• Ronaquine
• Rp 3377
• ST 121 (pharmaceutical)
• St 121
• N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
• Quinagamin
• Chlorquin
• Chloroquina
• 3377 RP
• Cocartrit
• Avlochlor
• Arthrochin
• Imagon
• Sopaquin
• Chingamin
• 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline
• WIN 244
• Bemaphate
• Quinachlor
• Nivaquine B
• -[7-Chloro-4-quinolinyl]-N',N'-diethyl-1,4-pentanediamine
• Lapaquin
• SN 6718
• Cidanchin
• Quinoscan
• 7-CHLORO-4-(4-DIMETHYLAMINO-1-METHYLBUTYLAMINO)QUINOLINE
• Delagil
• Diphenylhydramine
• Nivaquine
• Bemasulph
• Elestol
• w7618
• 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-quinolin
• n(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-4-pentanediamine
• Resoquine
• Tanakan
• nivaquineb
• Arechin
• SN 7618
• Benaquin
• W 7618
• Mesylith
• Silbesan
• Sanoquin
• Quinercyl
• N(sup4)-(7-chloro-4-quinolinyl)-N(sup1),N(sup1)-diethyl-1,4-pentanediamine
• Avloclor
• 4-(4-Diethylamino-1-methylbutylamino)-7-chloroquinoline
• Clorochina
• CHLOROQUINE
• 3377 RP opalate
• 4-(4-Diethylamino-1-methylbntyla-mino)-7-chloroquinoline
• Nivaquine [as sulfate]
• N
• Reumaquin
• Tresochin
• Malaquin
• 4
• Neochin
• Malarex
• Dichinalex
• Chloroquine (base and/or unspecified salts)
• Resochin
• Quingamine
• (7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline
• win244
• Cloroquine
• Nivachine
• Amokin
• Resochen
• rp3377
• Quinagamine
• Chemochin
• Gontochin
• 1,4-pentanediamine,n(sup4)-(7-chloro-4-quinolinyl)-n(sup1),n(sup1)-diethy
• Solprina
• sn7618
• Siragan
• Trochin
• Resoquina
• Malaren
• Chloroquinium
• N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diaMine
• Bemaco
• Heliopar
• Klorokin
• Roquine
• Iroquine
• Pfizerquine
• Chlorochine

Chloroquine

CAS: 54-05-7

Formula: C₁₈H₂₆ClN₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 319.8721

Ref: IN-DA00DDVD

N4-(7-Chloroquinolin-4-Yl)-N1,N1-Diethylpentane-1,4-Diamine

CAS: 54-05-7

N4-(7-Chloroquinolin-4-Yl)-N1,N1-Diethylpentane-1,4-Diamine

Purity: 97%

Molecular weight: 319.87g/mol

Ref: 54-OR1014213

Chloroquine

CAS: 54-05-7

Chloroquine

Purity: ≥95%

Molecular weight: 319.87g/mol

Ref: 54-BUP17107

Chloroquine

CAS: 54-05-7

Formula: C₁₈H₂₆ClN₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to lump

Molecular weight: 319.88

Ref: 3B-C3730

Chloroquine

CAS: 54-05-7

Chloroquine: antimalarial, anti-inflammatory, autophagy/TLRs inhibitor, treats arthritis, effective against COVID-19 in vitro. EC50: 1.13 μM.

Formula: C₁₈H₂₆ClN₃

Purity: 99.5% - 99.98%

Color and Shape: White To Slightly Yellow Crystalline Powder Solid

Molecular weight: 319.87

Ref: TM-T8689

Chloroquine

CAS: 54-05-7

Applications Chloroquine used in the treatment of malaria and MDR-strains. It is a COVID19-related research product.
References Laufer, M. et al.: PLoS One., 7, e42284 (2012); Hangartner, S. et al.: Drug Test. ANal., 5, 777 (2013)

Formula: C₁₈H₂₆ClN₃

Color and Shape: White To Light Brown

Molecular weight: 319.87

Ref: TR-C380318

Chloroquine

CAS: 54-05-7

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine is are an schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and the glycoprofile on the S-glycoprotein.

Formula: C₁₈H₂₆ClN₃

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 319.87 g/mol

Ref: 3D-FC150960

N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine

CAS: 54-05-7

Formula: C₁₈H₂₆ClN₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 319.88

Ref: 10-F242503