CAS 54-20-6: 5-(Trifluoromethyl)uracil

Description: 5-(Trifluoromethyl)uracil is a fluorinated derivative of uracil, a pyrimidine nucleobase that is a component of RNA. This compound features a trifluoromethyl group (-CF3) at the 5-position of the uracil ring, which significantly influences its chemical properties and biological activity. The presence of the trifluoromethyl group enhances lipophilicity and can affect the compound's interaction with biological targets, potentially altering its pharmacological profile. 5-(Trifluoromethyl)uracil exhibits characteristics typical of halogenated organic compounds, such as increased stability and resistance to metabolic degradation. It is often studied for its potential applications in medicinal chemistry, particularly in the development of antiviral and anticancer agents. The compound is typically solid at room temperature and may exhibit moderate solubility in organic solvents. Its reactivity can be influenced by the electron-withdrawing nature of the trifluoromethyl group, making it a valuable compound in synthetic organic chemistry and drug design. Safety and handling precautions should be observed due to the potential toxicity associated with fluorinated compounds.

Formula: C₅H₃F₃N₂O₂

InChI: InChI=1S/C5H3F3N2O2/c6-5(7,8)2-1-9-4(12)10-3(2)11/h1H,(H2,9,10,11,12)

InChI key: InChIKey=LMNPKIOZMGYQIU-UHFFFAOYSA-N

SMILES: O=C1NC=C(C(=O)N1)C(F)(F)F

Synonyms:

• 2,4(1H,3H)-Pyrimidinedione, 5-(trifluoromethyl)-
• 5-(Trifluoromethyl)-1,2,3,4-Tetrahydropyrimidine-2,4-Dione
• 5-(Trifluoromethyl)pyrimidine-2,4-diol
• 5-(trifluoromethyl)-2,4(1H,3H)-Pyrimidinedione
• 5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione
• 5-Trifluoromethyl-1H-pyrimidine-2,4-dione
• 5-Trifluoromethyluracil
• 5-Trifluorothymine
• NSC 73757
• Trifluorothymine
• Uracil, 5-(trifluoromethyl)-
• 5-(Trifluoromethyl)uracil

5-(Trifluoromethyl)uracil

CAS: 54-20-6

• Formula: C₅H₃F₃N₂O₂
• Purity: >97.0%(HPLC)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 180.09

5-(Trifluoromethyl)uracil

CAS: 54-20-6

• Formula: C₅H₃F₃N₂O₂
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 180.0847

Trifluorothymine

CAS: 54-20-6

• Formula: C₅H₃F₃N₂O₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 180.09

5-Trifluoromethyluracil

CAS: 54-20-6

• Formula: C₅H₃F₃N₂O₂
• Molecular weight: 180.08

5-(Trifluoromethyl)uracil

CAS: 54-20-6

• Purity: 97.0%
• Color and Shape: Solid
• Molecular weight: 180.08599853515625

5-(Trifluoromethyl)uracil

CAS: 54-20-6

• Formula: C₅H₃F₃N₂O₂
• Purity: 98%
• Color and Shape: solid
• Molecular weight: 180.08g/mol

5-Trifluorothymine

CAS: 54-20-6

Intermediate in the synthesis of tipiracil + trifluridine

• Formula: C₅H₃F₃N₂O₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 180.08 g/mol

Trifluorothymine

CAS: 54-20-6

Applications Trifluorothymine is an antitumor and antiviral agent. Trifluorothymine was found in patients’ urine as …

• Formula: C₅H₃F₃N₂O₂
• Color and Shape: Neat
• Molecular weight: 180.08