CAS 54-20-6

5-(Trifluoromethyl)uracil

Description:

5-(Trifluoromethyl)uracil is a fluorinated derivative of uracil, a pyrimidine nucleobase that is a component of RNA. This compound features a trifluoromethyl group (-CF3) at the 5-position of the uracil ring, which significantly influences its chemical properties and biological activity. The presence of the trifluoromethyl group enhances lipophilicity and can affect the compound's interaction with biological targets, potentially altering its pharmacological profile. 5-(Trifluoromethyl)uracil exhibits characteristics typical of halogenated organic compounds, such as increased stability and resistance to metabolic degradation. It is often studied for its potential applications in medicinal chemistry, particularly in the development of antiviral and anticancer agents. The compound is typically solid at room temperature and may exhibit moderate solubility in organic solvents. Its reactivity can be influenced by the electron-withdrawing nature of the trifluoromethyl group, making it a valuable compound in synthetic organic chemistry and drug design. Safety and handling precautions should be observed due to the potential toxicity associated with fluorinated compounds.

Formula: C₅H₃F₃N₂O₂

InChI: InChI=1S/C5H3F3N2O2/c6-5(7,8)2-1-9-4(12)10-3(2)11/h1H,(H2,9,10,11,12)

InChI key: InChIKey=LMNPKIOZMGYQIU-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C=1C(=O)NC(=O)NC1

Synonyms:

• 2,4(1H,3H)-Pyrimidinedione, 5-(trifluoromethyl)-
• 5-(Trifluoromethyl)-1,2,3,4-Tetrahydropyrimidine-2,4-Dione
• 5-(Trifluoromethyl)pyrimidine-2,4-diol
• 5-(trifluoromethyl)-2,4(1H,3H)-Pyrimidinedione
• 5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione
• 5-Trifluoromethyl-1H-pyrimidine-2,4-dione
• 5-Trifluoromethyluracil
• 5-Trifluorothymine
• NSC 73757
• Trifluorothymine
• Uracil, 5-(trifluoromethyl)-

5-(Trifluoromethyl)uracil

CAS: 54-20-6

Formula: C₅H₃F₃N₂O₂

Purity: >97.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 180.09

Ref: 3B-T1622

2-Chloro-4-methoxy-5-(trifluoromethyl)pyrimidine

CAS: 54-20-6

Formula: C₅H₃F₃N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 180.0847

Ref: IN-DA0037AB

Trifluorothymine

CAS: 54-20-6

Formula: C₅H₃F₃N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 180.09

Ref: 4Z-T-208001

5-Trifluoromethyluracil

CAS: 54-20-6

Formula: C₅H₃F₃N₂O₂

Molecular weight: 180.08

Ref: 7W-GK2183

5-(Trifluoromethyl)uracil

CAS: 54-20-6

5-(Trifluoromethyl)uracil

Formula: C₅H₃F₃N₂O₂

Purity: 98%

Color and Shape: solid

Molecular weight: 180.08g/mol

Ref: 54-PC7780

5-(Trifluoromethyl)uracil

CAS: 54-20-6

Formula: C₅H₃F₃N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 180.086

Ref: 10-F003333

5-Trifluorothymine

CAS: 54-20-6

Intermediate in the synthesis of tipiracil + trifluridine

Formula: C₅H₃F₃N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 180.08 g/mol

Ref: 3D-FT10650

Trifluorothymine

Controlled Product

CAS: 54-20-6

Applications Trifluorothymine is an antitumor and antiviral agent. Trifluorothymine was found in patients’ urine as a metabolite of Trifluorothymidine as cancer treatment.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cirak, C., et al.: J. Mol. Model., 18, 4453 (2012); Dexter, D., et al.: Cancer Res., 32, 247 (1972)

Formula: C₅H₃F₃N₂O₂

Color and Shape: Neat

Molecular weight: 180.08

Ref: TR-T793638

Trifluridine EP Impurity B

CAS: 54-20-6

Formula: C₅H₃F₃N₂O₂

Molecular weight: 180.09

Ref: ST-EA-CP-T185002