CAS 54-36-4

Metyrapone

Description:

Metyrapone is a synthetic compound primarily used in medical and research settings, particularly for its role as an adrenal steroid synthesis inhibitor. It is classified as a pyridine derivative and is known for its ability to inhibit the enzyme 11β-hydroxylase, which is crucial in the biosynthesis of cortisol. This inhibition leads to decreased cortisol production, making metyrapone useful in diagnosing adrenal insufficiency and in research related to the hypothalamic-pituitary-adrenal (HPA) axis. Metyrapone is typically administered orally and is characterized by its relatively low solubility in water, which can affect its bioavailability. The compound is generally considered to have a favorable safety profile when used under medical supervision, although it can cause side effects such as dizziness, nausea, and gastrointestinal disturbances. Its chemical structure includes a pyridine ring and a ketone functional group, contributing to its pharmacological activity. Overall, metyrapone serves as a valuable tool in both clinical and experimental endocrinology.

Formula: C₁₄H₁₄N₂O

InChI: InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3

InChI key: InChIKey=FJLBFSROUSIWMA-UHFFFAOYSA-N

SMILES: C(C(C)(C)C=1C=CC=NC1)(=O)C=2C=CC=NC2

Synonyms:

• 1,2-Bis(3-pyridyl)-2-methyl-1-propanone
• 1-Propanone, 2-methyl-1,2-di-3-pyridyl-
• 2-Methyl-1,2-bis(3-pyridyl)-1-propanone
• 2-Methyl-1,2-di(β-pyridyl)-1-propanone
• 2-Methyl-1,2-di-3-pyridinyl-1-propanone
• 2-Methyl-1,2-di-3-pyridyl-1-propanone
• Mepyrapone
• Methapyrapone
• Methbipyranone
• Methopirapone
• Methopyrapone
• Methopyrinine
• Methopyrone
• Metirapona
• Metopiron
• Metopirone
• Metopyrone
• Metroprione
• Metyrapon
• Metyrapone
• Nsc 25265
• Su 4885

Metyrapone

CAS: 54-36-4

Color and Shape: Neat

Ref: 61-FOR1694.00

Metyrapone

CAS: 54-36-4

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₄H₁₄N₂O

Color and Shape: White Powder

Molecular weight: 226.27 g/mol

Ref: 45-1443001

Metyrapone

CAS: 54-36-4

Formula: C₁₄H₁₄N₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 226.2738

Ref: IN-DA00D9QW

Metyrapone

CAS: 54-36-4

Metyrapone (NSC-25265) blocks steroid 11β-monooxygenase, used to diagnose Cushing's syndrome.

Formula: C₁₄H₁₄N₂O

Purity: 99.03% - ≥95%

Color and Shape: Crystals From Ether & Pentane Solid

Molecular weight: 226.27

Ref: TM-T0293

Metyrapone

CAS: 54-36-4

Metyrapone

Purity: ≥95%

Molecular weight: 226.27g/mol

Ref: 54-BUP14776

2-Methyl-1,2-Di(Pyridin-3-Yl)Propan-1-One

CAS: 54-36-4

2-Methyl-1,2-Di(Pyridin-3-Yl)Propan-1-One

Purity: 99%

Molecular weight: 226.27g/mol

Ref: 54-OR1010532

Metyrapone

CAS: 54-36-4

Formula: C₁₄H₁₄N₂O

Purity: (NMR) ≥ 98%

Color and Shape: White to off-white powder

Molecular weight: 226.27

Ref: 7W-GP8770

Metyrapone

CAS: 54-36-4

Formula: C₁₄H₁₄N₂O

Color and Shape: Neat

Molecular weight: 226.27

Ref: 86-MM1694.00

Metyrapone

CAS: 54-36-4

Applications Metyrapone acts as a glucocorticoid synthesis inhibitor, maintaining stress-hormone levels.
References Keller, C. et al.: Drug. Alc. Dep., 133, 405 (2013); Vilela, F. et al.: Neuroendocrinol., 97, 322 (2013);

Formula: C₁₄H₁₄N₂O

Color and Shape: Light Brown Solid

Molecular weight: 226.27

Ref: TR-M338990