CAS 54-42-2

5-Iodo-2′-deoxyuridine

Description:

5-Iodo-2′-deoxyuridine (IDU) is a nucleoside analog of thymidine, characterized by the presence of an iodine atom at the 5-position of the pyrimidine ring. It is primarily used in antiviral research and as a potential therapeutic agent in cancer treatment due to its ability to interfere with DNA synthesis. IDU is a white to off-white crystalline powder that is soluble in water and exhibits a moderate stability profile under physiological conditions. Its molecular formula is C₁₃H₁₂I N₃O₅, and it has a molecular weight that reflects its complex structure. The compound is known to inhibit viral replication, particularly in the context of herpes simplex virus, and is also studied for its effects on cellular processes. IDU can be incorporated into DNA during replication, leading to mutations and ultimately cell death, which is a mechanism exploited in cancer therapy. Safety and handling precautions are necessary due to its potential biological effects, and it should be used in controlled laboratory settings.

Formula: C₉H₁₁IN₂O₅

InChI: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI key: InChIKey=XQFRJNBWHJMXHO-RRKCRQDMSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(I)C(=O)N1

Synonyms:

• 1-(2-Dehydroxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-iodopyrimidine-2,4(1H,3H)-dione
• 2'-Desoxy-5-iodouridine
• 2-Deoxy-5-iodouridine
• 5-Iodo-2'-Deoxy-D-Uridine
• 5-Iodo-2'-desoxyuridine
• 5-Iodo-deoxyuridine
• 5-Iododeoxyuridine
• 5-Iodouracil deoxyriboside
• 5Iudr
• Allergan 211
• Dendrid
• Emanil
• Herpe-Gel
• Herpesil
• Herpidu
• Herplex
• IDU
• Idexur
• Idoxene
• Idoxuridin
• Idoxuridina
• Idoxuridine
• Idu Oculos
• Iducher
• Idulea
• Idur
• Iduridin
• Iododeoxyuridine
• Iudr
• Joddeoxiuridin
• Kerecid
• Nsc 39661
• Ophthalmadine
• Skf 14287
• Stoxil
• Stoxip
• Synmiol
• Uridine, 2'-deoxy-5-iodo-
• Virudox

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purity: >99.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 354.10

Ref: 3B-I0258

(+)-5-Iodo-2'-deoxyuridine, 98%

CAS: 54-42-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₉H₁₁IN₂O₅

Purity: 98%

Color and Shape: White to pale cream, Crystals or powder or crystalline powder

Molecular weight: 354.10

Ref: 02-A11542

IDOXURIDINE CRS

CAS: 54-42-2

IDOXURIDINE CRS

Formula: C₉H₁₁IN₂O₅

Color and Shape: Powder

Molecular weight: 354.0985

Ref: 41-I0050000

Idoxuridine

CAS: 54-42-2

Idoxuridine

Formula: C₉H₁₁IN₂O₅

Purity: 99.9%

Color and Shape: White

Molecular weight: 353.97127

Ref: 47-202

Idoxuridine

CAS: 54-42-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₉H₁₁IN₂O₅

Color and Shape: White Crystalline Powder

Molecular weight: 353.97127

Ref: 45-1336001

Idoxuridine

CAS: 54-42-2

Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.

Formula: C₉H₁₁IN₂O₅

Purity: 99.45% - 99.62%

Color and Shape: Crystals From Water Triclinic Solid

Molecular weight: 354.1

Ref: TM-T0863

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 354.0985

Ref: IN-DA003AAB

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

5-Iodo-2'-deoxyuridine

Purity: 99%

Molecular weight: 354.10g/mol

Ref: 54-OR72935

Idoxuridine

CAS: 54-42-2

Idoxuridine

Purity: ≥98%

Molecular weight: 354.1g/mol

Ref: 54-BUP18492

5-Iodo-2''-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purity: ≥ 98.5%

Color and Shape: White to off-white crystalline powder

Molecular weight: 354.10

Ref: 7W-GP1769

Idoxuridine

Controlled Product

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Color and Shape: Neat

Molecular weight: 354.10

Ref: 86-MM0791.00

Idoxuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Color and Shape: Neat

Molecular weight: 354.10

Ref: 04-C14278800

Idoxuridine RS

CAS: 54-42-2

Color and Shape: Colorless Or White

Ref: 2K-1015000021

Idoxuridine

Controlled Product

CAS: 54-42-2

Applications Idoxuridine is an antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.
References Chang, C., et al.: J. Biol. Chem., 267, 22414 (1992), Pressacco, J., et al.: Cancer Res., 54, 3772 (1994),

Formula: C₉H₁₁IN₂O₅

Color and Shape: Neat

Molecular weight: 354.10

Ref: TR-I205750

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a novel nucleoside that has antiviral and anticancer properties. It is an analog of uridine, which is the building block for RNA. 2'-Deoxy-5-iodouridine can be phosphorylated to form diphosphate, monophosphate, and triphosphate forms. It can also be modified to form phosphoramidites or deoxyribonucleosides. This drug has been shown to have anticancer effects on various types of cancer cells and has been used in the treatment of leukemia and other cancers.

Formula: C₉H₁₁IN₂O₅

Purity: Min. 99.0 Area-%

Molecular weight: 354.1 g/mol

Ref: 3D-Q-201230

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine (IDU) is a nucleoside that inhibits viral replication by inhibiting the synthesis of viral DNA. IDU has been shown to be a potent inhibitor of murine sarcoma virus and human immunodeficiency virus (HIV). IDU also has inhibitory properties on axonal growth, which may be due to its ability to inhibit DNA polymerase II. 2'-Deoxy-5-iodouridine is biocompatible, non-toxic, and can be used in high concentrations without any acute toxicities.

Formula: C₉H₁₁IN₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 354.1 g/mol

Ref: 3D-ND05147

2'-Deoxy-5-iodouridine - EP

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. 2'-Deoxy-5-iodouridine has been shown to inhibit the growth of human HL60 cells in vitro at an optimum concentration of 20 μM. It also inhibits the replication of murine sarcoma virus at an optimum concentration of 16 μM.
2'-Deoxy-5-iodouridine has significant cytotoxicity against solid tumours in mice, which may be due to its ability to inhibit hydrogen fluoride (HF) induced lipid peroxidation and reduce glutathione levels.

Formula: C₉H₁₁IN₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 354.1 g/mol

Ref: 3D-ND172114

5-Iodo-2′-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purity: 95%

Color and Shape: Solid, White powder

Molecular weight: 354.1

Ref: 10-F092965

5-Iodo-2-Deoxyuridine extrapure, 98%

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purity: min. 98%

Color and Shape: White to off-white, Crystalline powder

Molecular weight: 354.10

Ref: SR-83441

Idoxuridine

CAS: 54-42-2

Color and Shape: Neat

Ref: 61-FOR0791.00