CAS 54-91-1

Pipobroman

Description:

Pipobroman, with the CAS number 54-91-1, is a chemical compound classified as an alkylating agent, primarily used in the field of oncology as a chemotherapeutic agent. It is known for its ability to interfere with DNA synthesis, making it effective in the treatment of certain types of cancer, particularly hematological malignancies. The compound is characterized by its structure, which includes a bromine atom that plays a crucial role in its reactivity. Pipobroman is typically administered in a clinical setting, and its pharmacological effects are associated with its capacity to form covalent bonds with nucleophilic sites in DNA, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. However, like many alkylating agents, it can also exhibit toxicity, affecting normal, healthy cells and leading to side effects. Therefore, its use is carefully monitored in therapeutic contexts. Overall, Pipobroman represents a significant tool in cancer treatment, although its application requires a thorough understanding of its pharmacodynamics and potential adverse effects.

Formula: C₁₀H₁₆Br₂N₂O₂

InChI: InChI=1/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2

InChI key: InChIKey=NJBFOOCLYDNZJN-UHFFFAOYSA-N

SMILES: C(CCBr)(=O)N1CCN(C(CCBr)=O)CC1

Synonyms:

• 1,1′-(1,4-Piperazinediyl)bis[3-bromo-1-propanone]
• 1,1′-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
• 1,4-Bis(3-bromopropionyl)piperazine
• 1,4-Di(3-bromopropionyl)piperazine
• 1-Propanone, 1,1'-(1,4-piperazinediyl)bis[3-bromo-
• 3-Bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
• A 1803
• Amedel
• N,N'-Bis(3-bromopropionyl)piperazine
• Nsc-25154
• Piperazine, 1,4-bis(3-bromopropionyl)-
• Pipobroman
• Vercyte
• 1,1'-Piperazine-1,4-diylbis(3-bromopropan-1-one)
• Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-
• 1,4-Bis(3-bromopropanoyl)piperazine
• Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-
• 1,4-Bis-(3-bromo-1-oxopropyl)piperazine
• A-8103

Pipobroman

CAS: 54-91-1

Formula: C₁₀H₁₆Br₂N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 356.0542

Ref: IN-DA00DB7A

Pipobroman

CAS: 54-91-1

Pipobroman

Purity: ≥90%

Molecular weight: 356.05g/mol

Ref: 54-BUP14626

1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)

CAS: 54-91-1

1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)

Purity: 98%

Molecular weight: 356.05g/mol

Ref: 54-OR1026668

Pipobroman

CAS: 54-91-1

Pipobroman (Vercyte) is an alkylating anti-cancer drug effective in PV and ET with low toxicity and thrombosis risk.

Formula: C₁₀H₁₆Br₂N₂O₂

Purity: 97.08%

Color and Shape: Solid

Molecular weight: 356.05

Ref: TM-T4570

1,1′-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)

CAS: 54-91-1

Formula: C₁₀H₁₆Br₂N₂O₂

Purity: 95.0%

Molecular weight: 356.058

Ref: 10-F242508

Pipobroman-D8

Controlled Product

CAS: 54-91-1

Applications Pipobroman-D8 is a labelled analogue of Pipobroman (P490602).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: C₁₀H₈D₈Br₂N₂O₂

Color and Shape: Neat

Molecular weight: 364.1

Ref: TR-P490602

Pipobroman

Controlled Product

CAS: 54-91-1

Applications Pipobroman is a neutral amide of piperazine and is used as a chemotherapy drug to treat patients with polycythemia vera.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kiladjian, J., et al.: Hemat. J., 4, 198 (2013); Passamonti, F. & Lazzarino, M.: Leukemia Lymphoma, 44, 1483 (2003)

Formula: C₁₀H₁₆Br₂N₂O₂

Color and Shape: Neat

Molecular weight: 356.05

Ref: TR-P490600