CAS 54022-49-0

(3′α,4′α)-4′-Deoxy-3′,4′-epoxy-22-oxovincaleukoblastine

Description:

(3′α,4′α)-4′-Deoxy-3′,4′-epoxy-22-oxovincaleukoblastine, with the CAS number 54022-49-0, is a chemical compound that belongs to the class of alkaloids, specifically derived from the vinca plant. This compound is characterized by its complex structure, which includes a tetracyclic framework typical of vinca alkaloids, featuring a unique epoxy group and a ketone functional group. It exhibits biological activity, particularly in the context of cancer treatment, as many vinca alkaloids are known for their ability to inhibit microtubule formation, thereby disrupting cell division. The stereochemistry of the compound is significant, as the specific configuration of its chiral centers can influence its pharmacological properties and efficacy. Additionally, its solubility, stability, and interaction with biological targets are essential factors that determine its potential therapeutic applications. As with many alkaloids, safety and toxicity profiles are critical considerations in its use, necessitating thorough research and evaluation in clinical settings.

Formula: C₄₆H₅₄N₄O₁₀

InChI: InChI=1S/C46H54N4O10/c1-7-42-15-11-17-49-19-16-44(37(42)49)30-20-31(34(56-4)21-33(30)50(25-51)38(44)46(55,41(54)58-6)39(42)59-26(3)52)45(40(53)57-5)22-27-23-48(24-43(8-2)36(27)60-43)18-14-29-28-12-9-10-13-32(28)47-35(29)45/h9-13,15,20-21,25,27,36-39,47,55H,7-8,14,16-19,22-24H2,1-6H3

InChI key: InChIKey=GLDSBTCHEGZWCV-UHFFFAOYSA-N

SMILES: C(C)C12C3C4(C(C(C(OC)=O)(O)C1OC(C)=O)N(C=O)C=5C4=CC(=C(OC)C5)C6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CCN9CC(C6)C%10C(CC)(O%10)C9)CCN3CC=C2

Synonyms:

• (2alpha,2'beta,3alpha,3'beta,4alpha,5beta,19beta)-22-oxo-O~3~',3'-cyclovincaleukoblastine
• 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
• 22-Oxoleurosine
• 22-oxo-O~3~',3'-cyclovincaleukoblastine
• 2H-3,13-Methanooxireno[9,10]azacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
• 4'-Desoxy-3'alpha,4'alpha-epoxyvincristin
• F-Leurosine
• Formyl-leurosine
• Formylleurosine
• Leuroformine
• N-Demethyl-N-formylleurosine
• N-Formyl N-demethylleurosine
• N-Formylleurosine
• Nsc 269419
• Unii-I4U9Nzs9T5
• Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-22-oxo-, (3'-alpha,4'-alpha)- (9CI)
• Vincaleukoblastine, 4′-deoxy-3′,4′-epoxy-22-oxo-, (3′α,4′α)-
• Vinformida
• Vinformida [INN-Spanish]
• Vinformide
• Vinformide [INN]
• Vinformidum
• Vinformidum [INN-Latin]
• f-Leu

Vinformide

CAS: 54022-49-0

Vinformide is a potent cytostatic agent.

Formula: C₄₆H₅₄N₄O₁₀

Color and Shape: Solid

Molecular weight: 822.956

Ref: TM-T35057

Vincristine EP Impurity G (Formyl Leurosine)

CAS: 54022-49-0

Formula: C₄₆H₅₄N₄O₁₀

Molecular weight: 822.96

Ref: 4Z-V-193

N-Formyl Leurosine(>85%)

CAS: 54022-49-0

Impurity Vincristine Impurity G
Stability Hygroscopic
Applications Degradation products of Vincristine. A Vinca dimer, a potent cytostatic agent. Vincristine Impurity G.
References Erdelyi-Toth, V., et al.: Eur. J. Cancer, 17, 329 (1981), Ronai-Lukacs S; Eur. J. Drug Metab. Pharmacokinet., 7, 4 (1982),

Formula: C₄₆H₅₄N₄O₁₀

Purity: >85%

Color and Shape: Neat

Molecular weight: 822.94

Ref: TR-F700650

N-Formyl leurosine

CAS: 54022-49-0

N-Formyl leurosine is an inhibitor of fatty acid synthesis. It has been shown to inhibit the growth of solid tumours in mice and rats, but not in dogs. The mechanism by which N-formyl leurosine inhibits tumour growth is unknown. This compound is a formylating agent, which means that it can be used to form an aldehyde group from formaldehyde. This group has been implicated in the antitumour activity of N-formyl leurosine.

Formula: C₄₆H₅₄N₄O₁₀

Purity: Min. 95%

Molecular weight: 822.94 g/mol

Ref: 3D-IF23552