Vincaleukoblastine, also known as vincristine, is a natural alkaloid derived from the periwinkle plant, Vinca rosea. It is classified as a vinca alkaloid and is primarily used in chemotherapy for the treatment of various cancers, including leukemia and lymphoma. The compound exhibits a complex structure characterized by a tetracyclic framework, which contributes to its biological activity. Vincaleukoblastine functions by inhibiting microtubule formation during cell division, effectively disrupting the mitotic spindle and preventing cancer cell proliferation. Its pharmacological properties include significant antitumor activity, but it is also associated with a range of side effects, such as neurotoxicity and gastrointestinal disturbances. The compound is typically administered intravenously and is known for its potent effects even at low doses. Due to its mechanism of action and therapeutic applications, vincaleukoblastine remains an important agent in oncology, although its use is often accompanied by careful monitoring and supportive care to manage adverse effects.

Vincaleukoblastine, 4-deoxy-3,4-epoxy-, (3a,4a)-

54081-68-4: Vincaleukoblastine, also known as vincristine, is a natural alkaloid derived from the periwinkle plant, Vinca rosea. It is classified as a vinca alkaloid and is primarily used in chemotherapy for the treatment of various cancers, including leukemia and lymphoma. The compound exhibits a complex structure characterized by a tetracyclic framework, which contributes to its biological activity. Vincaleukoblastine functions by inhibiting microtubule formation during cell division, effectively disrupting the mitotic spindle and preventing cancer cell proliferation. Its pharmacological properties include significant antitumor activity, but it is also associated with a range of side effects, such as neurotoxicity and gastrointestinal disturbances. The compound is typically administered intravenously and is known for its potent effects even at low doses. Due to its mechanism of action and therapeutic applications, vincaleukoblastine remains an important agent in oncology, although its use is often accompanied by careful monitoring and supportive care to manage adverse effects.

Vinleurosine sulfate, extracted from Vinca rosea Linn, is a potent antineoplastic indole alkaloid along with three others.

Vinleurosine sulfate

<p>Applications A new antitumor derivative of Vinblastine; a dimeric Vinca alkaloid for cancer therapy.<br>References Chakravarty, et al.: J. Med. Chem., 26(5), 638 (1983), Christensson., et al.: Eu.r J. Biochem., 194, 755 (1990), Mayer, et al.: J. Med. Chem., 34, 3029 (1991), Yu, H., et al.: Clin. Biochem., 27, 75 (1994)<br></p>

CAS 54081-68-4

Vincaleukoblastine, 4-deoxy-3,4-epoxy-, (3a,4a)-

Vinleurosine sulfate

Ref: TM-T40620

Leurosine Sulfate

Ref: TR-L330800