CAS 54083-22-6

Zorubicin

Description:

Zorubicin is an anthracycline antibiotic and chemotherapeutic agent, primarily used in the treatment of various cancers, including leukemia and solid tumors. It is structurally related to doxorubicin and exhibits similar mechanisms of action, primarily through intercalation into DNA, which inhibits DNA and RNA synthesis, ultimately leading to cell death. Zorubicin is known for its potent antitumor activity, but it also carries a risk of cardiotoxicity, a common side effect associated with anthracyclines. The compound is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance its efficacy. Its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through the bile. Due to its potential side effects and the need for careful monitoring, Zorubicin is usually prescribed under strict medical supervision. As with other chemotherapeutic agents, the therapeutic regimen must be tailored to the individual patient, considering factors such as cancer type, stage, and overall health.

Formula: C₃₄H₃₅N₃O₁₀

InChI: InChI=1S/C34H35N3O10/c1-15-28(38)20(35)12-23(46-15)47-22-14-34(44,16(2)36-37-33(43)17-8-5-4-6-9-17)13-19-25(22)32(42)27-26(30(19)40)29(39)18-10-7-11-21(45-3)24(18)31(27)41/h4-11,15,20,22-23,28,38,40,42,44H,12-14,35H2,1-3H3,(H,37,43)/t15-,20-,22-,23-,28+,34-/m0/s1

InChI key: InChIKey=FBTUMDXHSRTGRV-BJISBDEGSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(=NNC(=O)C4=CC=CC=C4)C)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6

Synonyms:

• Benzoic acid, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide
• Benzoic acid, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide
• Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, (2S-cis)-
• Daunomycin benzoylhydrazone
• Mcmc 4222
• Rubidazon
• Zorubicin
• Benzoic acid, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide
• Rubidazone
• Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, (2S-cis)-
• Benzoic acid, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide

Zorubicin

CAS: 54083-22-6

Formula: C₃₄H₃₅N₃O₁₀

Molecular weight: 645.66

Ref: 7W-GP7511

Zorubicin

CAS: 54083-22-6

Zorubicin is a drug that belongs to the group of anthracyclines. It has been used in the treatment of various solid tumours, including breast cancer and skin cancer. Zorubicin inhibits the growth of cells by binding to DNA and inhibiting the synthesis of proteins needed for cell growth. Zorubicin also inhibits energy metabolism by preventing ATP production and can cause cardiac toxicity, as well as congestive heart failure. This drug also causes damage to erythrocytes and leukocytes through its hydrophobic effect. Zorubicin is a disulfide-containing compound with a molecular weight of 727 Da. The compound is highly hydrophobic, which may be due to its ability to form hydrogen bonds with other molecules and water molecules.

Purity: Min. 95%

Ref: 3D-FZ36706

Zorubicin

CAS: 54083-22-6

Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.

Formula: C₃₄H₃₅N₃O₁₀

Color and Shape: Solid

Molecular weight: 645.66

Ref: TM-T69130