CAS 54143-56-5

Flecainide acetate

Description:

Flecainide acetate is a pharmaceutical compound primarily used as an antiarrhythmic agent in the treatment of certain types of cardiac arrhythmias. It belongs to the class of sodium channel blockers, which work by inhibiting the influx of sodium ions during the depolarization phase of the cardiac action potential, thereby stabilizing the cardiac membrane and reducing excitability. The substance is typically administered in its acetate salt form, which enhances its solubility and bioavailability. Flecainide acetate is characterized by its relatively high lipophilicity, allowing it to penetrate cell membranes effectively. It has a moderate half-life, necessitating careful dosing to maintain therapeutic levels. Common side effects may include dizziness, visual disturbances, and potential proarrhythmic effects, particularly in patients with structural heart disease. Due to its potency, it is generally prescribed with caution, and regular monitoring of cardiac function is recommended during treatment. Overall, flecainide acetate is a critical medication in the management of specific arrhythmias, contributing to improved patient outcomes when used appropriately.

Formula: C₁₇H₂₀F₆N₂O₃·C₂H₄O₂

InChI: InChI=1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)

InChI key: InChIKey=RKXNZRPQSOPPRN-UHFFFAOYSA-N

SMILES: C(NCC1CCCCN1)(=O)C2=C(OCC(F)(F)F)C=CC(OCC(F)(F)F)=C2.C(C)(O)=O

Synonyms:

• 2,5-Bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide acetate
• 2,5-Bis-(2,2,2-trifluoroethoxy)-N-(2-piperidinylmethyl)benzamide acetate
• Almarytm
• Apocard
• Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, acetate (1:1)
• Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetate
• Ecrinal
• Flecainide acetate [USAN:JAN]
• Flecainide monoacetate
• N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate
• N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate
• N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate
• N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetate (1:1)
• R 818
• R 818 (pharmaceutical)
• Tambocor
• Unii-M8U465Q1Wq
• Flecainide acetate
• Flecainide acetate

Flecainide acetate, 98%

CAS: 54143-56-5

Sodium channel blocker

Formula: C₁₉H₂₄F₆N₂O₅

Purity: 98%

Color and Shape: White, Powder or crystals or crystalline powder

Molecular weight: 474.40

Ref: 02-J63527

FLECAINIDE ACETATE CRS

CAS: 54143-56-5

FLECAINIDE ACETATE CRS

Formula: C₁₇H₂₀F₆N₂O₃

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 414.3427

Ref: 41-F0120000

Flecainide acetate

CAS: 54143-56-5

Flecainide acetate

Formula: C₁₇H₂₀F₆N₂O₃C₂H₄O₂

Purity: 99.3%

Color and Shape: White

Molecular weight: 474.15894

Ref: 47-676

FLECAINIDE FOR SYSTEM SUITABILITY CRS

CAS: 54143-56-5

FLECAINIDE FOR SYSTEM SUITABILITY CRS

Formula: C₁₇H₂₀F₆N₂O₃

Molecular weight: 414.3427

Ref: 41-Y0001274

Flecainide Acetate

CAS: 54143-56-5

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₇H₂₀F₆N₂O₃·C₂H₄O₂

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 474.15894

Ref: 45-1270800

Flecainide acetate salt

CAS: 54143-56-5

Formula: C₁₇H₂₀F₆N₂O₃·C₂H₄O₂

Purity: 98.0 - 101.0 % (dried basis)

Color and Shape: White to slightly off-white crystalline powder

Molecular weight: 474.40

Ref: 7W-GP3700

Flecainide acetate

CAS: 54143-56-5

Flecainide acetate

Purity: ≥98%

Molecular weight: 474.39g/mol

Ref: 54-BUP06889

Flecainide Acetate

Controlled Product

CAS: 54143-56-5

Formula: C₁₇H₂₀F₆N₂O₃·C₂H₄O₂

Color and Shape: Neat

Molecular weight: 474.39

Ref: 86-MM0488.00

Flecainide Acetate

CAS: 54143-56-5

Formula: C₁₇H₂₀F₆N₂O₃·C₂H₄O₂

Purity: >98.0%(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 474.40

Ref: 3B-B6459

Flecainide acetate

CAS: 54143-56-5

Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).

Formula: C₁₉H₂₄F₆N₂O₅

Purity: 99.42%

Color and Shape: Solid

Molecular weight: 474.39

Ref: TM-T7219

Flecainide Acetate

CAS: 54143-56-5

Applications Flecainide is an antiarrhythmic (class IC).
References Hodess, A.B., et al.: J. Cardiovasc. Pharmacol., 1, 427 (1979), Somani, P., et al.: Clin. Pharmacol. Ther., 27, 464 (1980), Alessi-Severini, S., et al.: Anal. Profiles Drug Subs. Excip., 21, 169 (1992)

Formula: C₁₇H₂₀F₆N₂O₃·C₂H₄O₂

Color and Shape: White

Molecular weight: 474.39

Ref: TR-F390010

Flecainide acetate

Controlled Product

CAS: 54143-56-5

Sodium channel blocker; anti-arrhythmic

Formula: C₁₇H₂₀F₆N₂O₃·C₂H₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 474.40 g/mol

Ref: 3D-FF36707