CAS 5418-95-1

2-Guanidinobenzimidazole

Description:

2-Guanidinobenzimidazole is an organic compound characterized by its unique structure, which features a benzimidazole ring substituted with a guanidine group. This compound is known for its potential biological activities, including its role as a nitric oxide synthase inhibitor and its involvement in various biochemical pathways. It typically appears as a white to off-white crystalline solid and is soluble in polar solvents. The presence of both the guanidine and benzimidazole moieties contributes to its basicity and reactivity, making it a subject of interest in medicinal chemistry and pharmacology. Additionally, 2-Guanidinobenzimidazole has been studied for its potential applications in the treatment of various diseases, including diabetes and cardiovascular conditions, due to its ability to modulate nitric oxide levels in biological systems. Safety and handling precautions should be observed, as with many chemical substances, to mitigate any potential hazards associated with its use.

Formula: C₈H₉N₅

InChI: InChI=1/C8H9N5/c9-7(10)13-8-11-5-3-1-2-4-6(5)12-8/h1-4H,(H5,9,10,11,12,13)/p+1

InChI key: InChIKey=JJWCTKUQWXYIIU-UHFFFAOYSA-N

SMILES: N(C(=N)N)C=1NC=2C(N1)=CC=CC2

Synonyms:

• (1H-Benzimidazol-2-yl)guanidine
• (E)-N-(1H-benzimidazol-2-yl)(imino)methanediaminium dichloride
• 1-(1H-1,3-Benzimidazol-2-yl)guanidine
• 1-(1H-1,3-Benzodiazol-2-yl)guanidine
• 1-(1H-Benzimidazol-2-yl)guanidine
• 1-(1H-Benzo[d]imidazol-2-yl)guanidine
• 1-(Benzimidazol-2-Yl)Guanidine
• 2-(1H-benzimidazol-2-yl)guanidine
• 2-Benzimidazolylguanidine
• Guanidine, (2-benzimidazolyl)-
• Guanidine, 1H-benzimidazol-2-yl-
• Guanidine, N-1H-benzimidazol-2-yl-
• N-(diaminomethylidene)-1H-benzimidazol-2-aminium
• N-1H-Benzimidazol-2-ylguanidine
• NSC 10548
• 2-Guanidinobenzimidazole
• OTAVA-BB BB0111070250
• TIMTEC-BB SBB003790
• AKOS BC-1905
• 2-(Diaminomethyleneamino)-1H-benzimidazole
• TOSLAB-BB TOS-BB-1283
• 1h-benzimidazol-2-yl-guanidin
• Guanidine, 1H-benzimidazol-2-yl-(9CI)
• N-1H-benzimidazol-2-ylguanidine hydrate
• 2-GUANIDINOBENZIMIDAZOLE 95%

2-Guanidinobenzimidazole

CAS: 5418-95-1

Formula: C₈H₉N₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 175.1906

Ref: IN-DA00D7YG

2-Guanidinobenzimiazole

CAS: 5418-95-1

2-Guanidinobenzimiazole

Purity: 95%

Molecular weight: 175.19g/mol

Ref: 54-OR54411

1-(1H-BENZO[D]IMIDAZOL-2-YL)GUANIDINE

CAS: 5418-95-1

Formula: C₈H₉N₅

Purity: 95%

Molecular weight: 175.195

Ref: 10-F531303

2-Guanidinobezimidazole

CAS: 5418-95-1

2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).

Formula: C₈H₉N₅

Color and Shape: Solid

Molecular weight: 175.191

Ref: TM-T206771