CAS 54193-28-1: Doxorubicinol

Description: Doxorubicinol, with the CAS number 54193-28-1, is a metabolite of the anthracycline antibiotic doxorubicin, which is widely used in cancer therapy. This compound retains some of the pharmacological properties of its parent drug, including antitumor activity, but has a different profile in terms of efficacy and toxicity. Doxorubicinol is characterized by its ability to intercalate DNA, disrupting the replication process and leading to cell death, which is a common mechanism of action among anthracyclines. It is typically less potent than doxorubicin but can contribute to the overall therapeutic effects in patients undergoing treatment. The compound is also known for its potential cardiotoxicity, a side effect associated with doxorubicin, although the extent may vary. In terms of physical properties, doxorubicinol is a red-orange crystalline solid, soluble in water and organic solvents, which facilitates its formulation for clinical use. Its chemical structure includes a tetracyclic ring system, characteristic of anthracyclines, contributing to its biological activity.

Formula: C₂₇H₃₁NO₁₁

InChI: InChI=1S/C27H31NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15-17,22,29-31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,16-,17-,22+,27-/m0/s1

InChI key: InChIKey=NKZRZOVSJNSBFR-FEMMEMONSA-N

SMILES: O=C1C=2C=CC=C(OC)C2C(=O)C=3C(O)=C4C(=C(O)C13)CC(O)(CC4OC5OC(C)C(O)C(N)C5)C(O)CO

Synonyms:

• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(1,2-dihydroxyethyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, [8S-[8α,8(R*),10α]]-
• 13-Dihydrodoxorubicin
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
• (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
• Adriamycinol

Doxorubicinol HCl (Mixture of Diasteromers)

CAS: 1242592-26-2 54193-28-1

• Formula: C₂₇H₃₁NO₁₁·HCl
• Molecular weight: 545.54 36.46

Doxorubicinol hydrochloride

CAS: 54193-28-1

• Formula: C₂₇H₃₂ClNO₁₁
• Purity: ≥ 90.0% (sum of isomers)
• Color and Shape: Red to dark red/brown powder
• Molecular weight: 582.0

Doxorubicinol

CAS: 54193-28-1

Doxorubicinol is the major circulating metabolite of doxorubicin with antineoplastic acitivity.

• Formula: C₂₇H₃₁NO₁₁
• Color and Shape: Solid
• Molecular weight: 545.54

Doxorubicinol Hydrochloride (>90%)(Mixture of diastereomers)

CAS: 54193-28-163950-05-0

Applications A metabolite of Doxorubicin as neoplasm inhibitor. References Smith, T.H.

• Formula: C₂₇H₃₁NO₁₁•HCl
• Color and Shape: Red
• Molecular weight: 545.54 + 36.46

Doxorubicinol (>90%)

CAS: 54193-28-1

Applications Doxorubicinol is a cardiotoxic metabolite of Doxorubicin (D558000). Used as an antineoplastic. References Freeland, …

• Formula: C₂₇H₃₁NO₁₁
• Purity: >90%
• Color and Shape: Neat
• Molecular weight: 545.54

Doxorubicinol,mixture of diastereomers

CAS: 54193-28-1

Please enquire for more information about Doxorubicinol,mixture of diastereomers including the price, delivery time and …

• Formula: C₂₇H₃₁NO₁₁
• Purity: (%) Min. 90%
• Molecular weight: 545.54 g/mol