CAS 54397-85-2

TXB2

Description:

TXB2, or thromboxane B2, is a stable metabolite of thromboxane A2, which is a potent vasoconstrictor and platelet aggregator. It is a member of the eicosanoid family, derived from arachidonic acid through the action of cyclooxygenase enzymes. TXB2 is characterized by its role in the cardiovascular system, particularly in promoting platelet aggregation and vasoconstriction, which are crucial for hemostasis. It is often measured in biological samples as a marker of platelet activation and cardiovascular health. The substance is typically found in low concentrations in the bloodstream and is rapidly metabolized, making its detection important in clinical and research settings. TXB2 does not possess the same biological activity as its precursor, thromboxane A2, but serves as an important indicator of thromboxane synthesis and platelet function. Its CAS number, 54397-85-2, is used for identification in chemical databases and regulatory contexts.

Formula: C₂₀H₃₄O₆

InChI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1

InChI key: InChIKey=XNRNNGPBEPRNAR-JQBLCGNGSA-N

SMILES: C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)OC(O)C[C@@H]1O

Synonyms:

• (5Z)-7-[(2R,3S,4S)-Tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-5-heptenoic acid
• (5Z)-7-{(2R,3S,4S)-4,6-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]tetrahydro-2H-pyran-3-yl}hept-5-enoic acid (non-preferred name)
• 5-Heptenoic acid, 7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-, (5Z)-
• 5-Heptenoic acid, 7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octenyl]-2H-pyran-3-yl]-, (5Z)-
• 8-(1-Hydroxy-3-oxopropyl)-9,12-dihydroxy-5,10-heptadecadienoic acid hemiacetal
• TXB₂
• Thromboxa-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,13E,15S)-
• Thromboxane B2
• Thromboxane B₂

Thromboxane B2

CAS: 54397-85-2

Formula: C₂₀H₃₄O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 370.4804

Ref: IN-DA00D8ZH

Thromboxane B2

CAS: 54397-85-2

Formula: C₂₀H₃₄O₆

Molecular weight: 370.48

Ref: 7W-GL2526

Thromboxane B2

CAS: 54397-85-2

Formula: C₂₀H₃₄O₆

Molecular weight: 370.49

Ref: 4Z-T-722

Thromboxane B2-d7

CAS: 54397-85-2

Formula: C₂₀H₂₇D₇O₆

Molecular weight: 377.53

Ref: 4Z-T-723

Thromboxane B2

Controlled Product

CAS: 54397-85-2

Applications An inactive metabolite/product of Thromboxane A2 (TBXA2): a compound involved in platelet activation and aggregation in case of a wound. Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis while measurement of 11-dehydro TBX2 (D230555) and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2 secretion.
References Needleman, P. et al.: Nature, 261, 558 (1976); Patrono, C. et al.: J Clin. Invest., 77, 590 (1986); Patrono, C. et al.: Adv. Prostaglandin Thromboxane Leukot. Res., 11, 493 (1983);

Formula: C₂₀H₃₄O₆

Color and Shape: Neat

Molecular weight: 370.48

Ref: TR-T405600

Thromboxane B2

CAS: 54397-85-2

Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces platelet aggregation and arterial contraction.

Formula: C₂₀H₃₄O₆

Color and Shape: Solid

Molecular weight: 370.48

Ref: TM-T41246

Thromboxane B2

CAS: 54397-85-2

Formula: C₂₀H₃₄O₆

Molecular weight: 370.49

Ref: ST-EA-CP-T211004