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CAS 54397-85-2

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TXB2

Description:
TXB2, or thromboxane B2, is a stable metabolite of thromboxane A2, which is a potent vasoconstrictor and platelet aggregator. It is a member of the eicosanoid family, derived from arachidonic acid through the action of cyclooxygenase enzymes. TXB2 is characterized by its role in the cardiovascular system, particularly in promoting platelet aggregation and vasoconstriction, which are crucial for hemostasis. It is often measured in biological samples as a marker of platelet activation and cardiovascular health. The substance is typically found in low concentrations in the bloodstream and is rapidly metabolized, making its detection important in clinical and research settings. TXB2 does not possess the same biological activity as its precursor, thromboxane A2, but serves as an important indicator of thromboxane synthesis and platelet function. Its CAS number, 54397-85-2, is used for identification in chemical databases and regulatory contexts.
Formula:C20H34O6
InChI:InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1
InChI key:InChIKey=XNRNNGPBEPRNAR-JQBLCGNGSA-N
SMILES:C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)OC(O)C[C@@H]1O
Synonyms:
  • (5Z)-7-[(2R,3S,4S)-Tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-5-heptenoic acid
  • (5Z)-7-{(2R,3S,4S)-4,6-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]tetrahydro-2H-pyran-3-yl}hept-5-enoic acid (non-preferred name)
  • 5-Heptenoic acid, 7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-, (5Z)-
  • 5-Heptenoic acid, 7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octenyl]-2H-pyran-3-yl]-, (5Z)-
  • 8-(1-Hydroxy-3-oxopropyl)-9,12-dihydroxy-5,10-heptadecadienoic acid hemiacetal
  • TXB<sub>2</sub>
  • Thromboxa-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,13E,15S)-
  • Thromboxane B2
  • Thromboxane B<sub>2</sub>
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