CAS 544686-21-7

Celecoxib-d7

CAS: 544686-21-7

Formula: C₁₇H₇D₇F₃N₃O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 388.42

Ref: 4Z-C-031

Celecoxib-d7 (tolyl-d7)

CAS: 544686-21-7

Purity: 99 atom % D

Color and Shape: Off White To Yellow Solid

Molecular weight: 388.41

Ref: 3U-D7317

Celecoxib-d7

Controlled Product

CAS: 544686-21-7

Applications Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998); Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000); Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000)

Formula: C₁₇D₇H₇F₃N₃O₂S

Color and Shape: White

Molecular weight: 388.42

Ref: TR-C251004

Celecoxib-d7

Controlled Product

CAS: 544686-21-7

Celecoxib-d7 is a drug that is metabolized by the cytochrome P450 system. It is an atypical compound that produces a concentration-dependent inhibition of human liver cytochrome P450. Celecoxib-d7 has been shown to inhibit the metabolism of other drugs, such as indomethacin, phenacetin, and sulfamethoxazole, which are substrates for CYP1A2. The matrix effect can be controlled by the addition of a small amount of quinidine to the incubation medium. This drug also binds allosterically to the enzyme cytochrome P450, which leads to changes in its kinetics and molecular modeling properties. The clinical studies have shown that celecoxib-d7 affects plasma concentrations in a dose-proportional manner and does not have any significant effects on plasma protein binding.

Formula: C₁₇H₁₄F₃N₃O₂S

Purity: Min. 95%

Molecular weight: 388.4 g/mol

Ref: 3D-UWA68621