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CAS 54527-84-3

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Nicardipine hydrochloride

Description:
Nicardipine hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It functions by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. This compound is characterized by its chemical formula, which includes a dihydropyridine structure, contributing to its pharmacological activity. Nicardipine hydrochloride is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. The substance appears as a white to off-white crystalline powder and is soluble in water and alcohol. Its mechanism of action involves selective inhibition of L-type calcium channels, which helps to relax blood vessels and improve blood flow. Common side effects may include headache, flushing, and peripheral edema. As with any medication, it is essential to monitor for potential interactions with other drugs and to consider patient-specific factors when prescribing nicardipine hydrochloride.
Formula:C26H29N3O6·ClH
InChI:InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
InChI key:InChIKey=AIKVCUNQWYTVTO-UHFFFAOYSA-N
SMILES:C(OCCN(CC1=CC=CC=C1)C)(=O)C=2C(C(C(OC)=O)=C(C)NC2C)C3=CC(N(=O)=O)=CC=C3.Cl
Synonyms:
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride
  • 2-[Benzyl(Methyl)Amino]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Hydrochloride (1:1)
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, hydrochloride (1:1)
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester, monohydrochloride
  • Antagonyl
  • Barizin
  • Bionicard
  • Cardene
  • Cardene (pharmaceutical)
  • Cardene SR
  • See more synonyms
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