CAS 546-06-5

(+)-Conessine

Description:

(+)-Conessine is an alkaloid derived from the plant species of the genus Holarrhena, particularly Holarrhena antidysenterica. It is characterized by its complex molecular structure, which includes a tetracyclic framework. This compound exhibits a range of biological activities, including potential anti-inflammatory, antidiarrheal, and antimicrobial properties. (+)-Conessine is known for its role in traditional medicine, particularly in treating gastrointestinal disorders. The substance is typically found in the form of a white to off-white crystalline powder and is soluble in organic solvents but has limited solubility in water. Its stereochemistry is significant, as the (+) designation indicates the specific optical activity of the molecule, which can influence its biological interactions. As with many alkaloids, (+)-Conessine's pharmacological effects are of interest in medicinal chemistry, and ongoing research continues to explore its potential therapeutic applications. Safety and toxicity profiles are essential considerations in its use, particularly in herbal medicine contexts.

Formula: C₂₄H₄₀N₂

InChI: InChI=1/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19?,20+,21?,22?,23-,24-/m0/s1

InChI key: InChIKey=GPLGAQQQNWMVMM-MYAJQUOBSA-N

SMILES: C[C@H]1[C@@]2([C@@]3([C@]([C@]4([C@](CC3)([C@]5(C)C(=CC4)C[C@@H](N(C)C)CC5)[H])[H])(CC2)[H])CN1C)[H]

Synonyms:

• (3-beta)-N,N-Dimethylcon-5-enin-3-amine
• (3alpha,8xi,9xi,10alpha,14xi,17beta)-N,N-dimethylcon-5-enin-3-amine
• (3beta,8xi,9xi,14xi,17xi)-N,N-dimethylcon-5-enin-3-amine
• (3β)-N,N-Dimethylcon-5-enin-3-amine
• 1H-Naphth[2′,1′:4,5]indeno[1,7a-c]pyrrole, con-5-enin-3-amine deriv.
• 3beta-(Dimethylamino)con-5-ene
• 3beta-(Dimethylamino)con-5-enine
• Brn 4702160
• Con-5-enin-3-amine, N,N-dimethyl-, (3beta)- (9CI)
• Con-5-enin-3-amine, N,N-dimethyl-, (3β)-
• Con-5-enine, 3beta-(dimethylamino)- (8CI)
• Con-5-enine, 3β-(dimethylamino)-
• Conesina
• Conesina [INN-Spanish]
• Conessin
• Conessine [INN]
• Conessinum
• Conessinum [INN-Latin]
• Conkurchine, N,18-dihydrotrimethyl-
• Conkurchine, N,18-dihydrotrimethyl- (7CI)
• Konessin
• N,N-dimethylcon-5-enin-3-amine
• Neriine
• Nsc 119994
• N′,18-Dihydro-N,N,N′-trimethylconkurchine
• Roquessine
• Unii-Ez38J9Bbdf
• Wrightine
• Conessine
• Conessine
• n,18-dihydrotrimethyl-conkurchin
• 3-beta-(dimethylamino)con-5-enine
• 5-CONENIN-3BETA-DIMETHYLAMINE
• ROGUESSINE
• 3-beta-(dimethylamino)-con-5-enin
• Conessine (Wrightine Roguessine)
• CONESSINE(P)
• N,N-Dimethyl-con-5-enin-3-amine
• CONESSINE(RG)
• (3β)-N,N-dimethyl-con-5-enin-3-amine
• n-dimethyl-(3-beta)-con-5-enin-3-amin
• (3-BETA)-N,N-DIMETHYL-CON-5-ENIN-3-AMINE

Conessine

CAS: 546-06-5

Formula: C₂₄H₄₀N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 356.5878

Ref: IN-DA003P1J

Conessine

CAS: 546-06-5

Conessine

Purity: ≥98%

Molecular weight: 356.59g/mol

Ref: 54-BUP02152

Conessine

CAS: 546-06-5

Formula: C₂₄H₄₀N₂

Purity: ≥ 97.0%

Color and Shape: White to tan powder

Molecular weight: 356.59

Ref: 7W-GP0961

Conessine

CAS: 546-06-5

Conessine

Formula: C₂₄H₄₀N₂

Purity: By hplc: 99.64% (Typical Value in Batch COA)

Color and Shape: white crystalline powder

Molecular weight: 356.59g/mol

Ref: 54-BIDF1033

Conessine

CAS: 546-06-5

Conessine (Conessinum), a steroidal alkaloid isolated from Holarrhena floribunda, interacts with the histamine H3 receptor and has anti-malarial activity.

Formula: C₂₄H₄₀N₂

Purity: 99.65%

Color and Shape: Solid

Molecular weight: 356.59

Ref: TM-T20712

Conessine

CAS: 546-06-5

Natural alkaloid

Formula: C₂₄H₄₀N₂

Purity: ≥ 90.0 % (HPLC)

Molecular weight: 356.59

Ref: 5G-86246

Conessine

CAS: 546-06-5

Conessine is an alkaloid compound, which is derived from the bark of certain plants, most notably from the family Apocynaceae, including Holarrhena antidysenterica. It is a steroidal alkaloid exhibiting adrenergic antagonist activity. Conessine primarily functions by blocking adrenergic receptors, which inhibits certain neurotransmitter activities, specifically those involving adrenaline and noradrenaline. This blockade can affect various physiological pathways, particularly those related to the sympathetic nervous system.

Formula: C₂₄H₄₀N₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 356.59 g/mol

Ref: 3D-FC57645