CAS 54639-48-4

Diphenylmethyl (6R,7R)-3-hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Description:

Diphenylmethyl (6R,7R)-3-hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, with CAS number 54639-48-4, is a complex organic compound characterized by its bicyclic structure, which includes a thiazolidine ring and an azabicyclo framework. This compound features multiple functional groups, including a hydroxyl group, a carbonyl group, and an amide linkage, contributing to its potential biological activity. The presence of the diphenylmethyl group suggests significant lipophilicity, which may influence its solubility and interaction with biological membranes. The stereochemistry indicated by the (6R,7R) configuration is crucial for its biological activity, as stereoisomers can exhibit different pharmacological effects. This compound may be of interest in medicinal chemistry, particularly in the development of pharmaceuticals, due to its structural complexity and the presence of sulfur and nitrogen atoms, which can enhance its reactivity and binding properties. Further studies would be necessary to elucidate its specific biological functions and potential therapeutic applications.

Formula: C₂₈H₂₄N₂O₅S

InChI: InChI=1S/C28H24N2O5S/c31-21-17-36-27-23(29-22(32)16-18-10-4-1-5-11-18)26(33)30(27)24(21)28(34)35-25(19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,23,25,27,31H,16-17H2,(H,29,32)/t23-,27-/m1/s1

InChI key: InChIKey=HJINVAQLVZRFTL-YIXXDRMTSA-N

SMILES: C(OC(C1=CC=CC=C1)C2=CC=CC=C2)(=O)C=3N4[C@@]([C@H](NC(CC5=CC=CC=C5)=O)C4=O)(SCC3O)[H]

Synonyms:

• (1S,8R)-4-Hydroxy-7-oxo-8-phenylacetylamino-2-thia-bicyclo[4.2.0]oct-4-ene-5-carboxylic acid benzhydryle
• (6R,7R)-3-Hydroxy-8-oxo-7-[(phenylacetyl)amino]-5-thia-1-azabicyclo
• (6R,7R)-3-Hydroxy-8-oxo-7-[(phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenyl methyl ester
• 3-Oh
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-, (6R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-hydroxy-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-hydroxy-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R-trans)-
• 7-Phenyl acetamido-3-Hydroxy-3-Cephem-4-Carboxylic acid Diphenylmethyl ester
• 7-Phenylacetamido-3-hydroxy-3-cephem-4-carboxylic acid diphenylmethyl ester
• Benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-hydroxy-3-cephem-4-carboxylate
• Diphenylmethyl (6R,7R)-3-hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-hydroxy-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester,(6R,7R)-

CAS: 54639-48-4

Formula: C₂₈H₂₄N₂O₅S

Purity: 95%

Color and Shape: Solid

Molecular weight: 500.5656

Ref: IN-DA00I9RH

Ceftaroline Fosamil Impurity 25 and Ceftaroline Fosamil Impurity 26 (Equilibrium Form)

CAS: 51761-81-0, 54639-48-4

Formula: C₂₈H₂₄N₂O₅S

Molecular weight: 500.57

Ref: 4Z-C-158041

3-hydroxycephem

CAS: 54639-48-4

3-hydroxycephem

Purity: ≥95%

Molecular weight: 500.57g/mol

Ref: 54-BUP13947

3-hydroxycephem

CAS: 54639-48-4

3-hydroxycephem is a useful organic compound for research related to life sciences. The catalog number is T4581 and the CAS number is 54639-48-4.

Formula: C₂₈H₂₄N₂O₅S

Purity: 98.74%

Color and Shape: White Or Off-White Crysalline Powder

Molecular weight: 500.57

Ref: TM-T4581

3(6R,7R)-Hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Diphenylmethyl Ester (>90%)

Controlled Product

CAS: 54639-48-4

Applications 3(6R,7R)--Hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Diphenylmethyl Ester is a useful synthetic intermediate. It was used to prepare cephalosporin-derived inhibitors. It can also be used to synthesize Ceftaroline Fosamil which is a cephalosporin antibiotic.
References Buynak, J., et al.: Bioorg. Med. Chem. Lett., 12, 1663 (2002); Kanafani, Z., et al.: Future Microbiology, 4, 25 (2009); Parish, D,, et al.: Curr. Opinion Invest. Drugs, 9, 201 (2000)

Formula: C₂₈H₂₄N₂O₅S

Purity: >90%

Color and Shape: Neat

Molecular weight: 500.57

Ref: TR-H949485

Ceftaroline Impurity 1

CAS: 54639-48-4

Formula: C₂₈H₂₄N₂O₅S

Molecular weight: 500.57

Ref: ST-EA-CP-C138003

Ceftaroline Fosamil Impurity 25

CAS: 54639-48-4

Formula: C₂₈H₂₄N₂O₅S

Molecular weight: 500.57

Ref: 4Z-C-158027