CAS 5471-90-9

N-(4-Hydroxyphenyl)benzenesulfonamide

Description:

N-(4-Hydroxyphenyl)benzenesulfonamide, also known as sulfanilamide, is an organic compound characterized by its sulfonamide functional group attached to a phenyl ring with a hydroxyl group in the para position. This compound typically appears as a white to off-white crystalline solid and is soluble in polar solvents such as water and alcohols, owing to the presence of the sulfonamide and hydroxyl groups, which can engage in hydrogen bonding. It exhibits properties that make it useful in various applications, including pharmaceuticals, where it may serve as an intermediate in the synthesis of other compounds or as an active ingredient in certain medications. The compound's structure allows it to participate in various chemical reactions, including electrophilic aromatic substitution and nucleophilic attacks, making it versatile in organic synthesis. Additionally, it may exhibit biological activity, which can be explored in medicinal chemistry. Safety data should be consulted for handling and usage, as with all chemical substances.

Formula: C₁₂H₁₁NO₃S

InChI: InChI=1/C12H11NO3S/c14-11-8-6-10(7-9-11)13-17(15,16)12-4-2-1-3-5-12/h1-9,13-14H

InChI key: InChIKey=WHZPMLXZOSFAKY-UHFFFAOYSA-N

SMILES: S(NC1=CC=C(O)C=C1)(=O)(=O)C2=CC=CC=C2

Synonyms:

• 4-Benzenesulfonamido phenol
• Benzenesulfonanilide, 4′-hydroxy-
• NSC 28472
• benzenesulfonamide, N-(4-hydroxyphenyl)-
• p-Benzenesulfonamido phenol
• N-(4-Hydroxyphenyl)benzenesulfonamide
• N-(4-Hydroxyphenyl)benzenesulfonamide
• benzenesulfon amidophenol
• enzenesulfonamide, N-(4-hydroxyphenyl)-

N-(4-Hydroxyphenyl)benzenesulfonamide

CAS: 5471-90-9

Formula: C₁₂H₁₁NO₃S

Molecular weight: 249.2856

Ref: IN-DA019Y3V

N-(4-Hydroxyphenyl)benzenesulfonamide

CAS: 5471-90-9

Formula: C₁₂H₁₁NO₃S

Purity: 99.0%

Molecular weight: 249.28

Ref: 10-F181571

N-(4-Hydroxyphenyl)benzenesulfonamide

CAS: 5471-90-9

N-(4-Hydroxyphenyl)benzenesulfonamide (NPSA) is a potentiator of chlorine that increases the activity of monooxygenases, such as epoxide hydrolase. NPSA also has the ability to inhibit glutathione synthesis in the liver and kidneys. This inhibition leads to liver cell necrosis. It is believed that NPSA may act by inhibiting the synthesis of an intermediate in the biosynthesis of cholesterol, 3-methylcholanthrene. The chlorobenzenesulfonamide moiety reacts with glutathione to form a reactive chloride ion, which then reacts with other cellular components to cause damage.

Formula: C₁₂H₁₁NO₃S

Purity: Min. 95%

Molecular weight: 249.29 g/mol

Ref: 3D-FAA47190