CAS 547730-06-3

Terazosin EP Impurity O

Description:

Terazosin EP Impurity O, with the CAS number 547730-06-3, is a chemical compound that is recognized as an impurity associated with the pharmaceutical agent terazosin, which is primarily used to treat hypertension and benign prostatic hyperplasia. As an impurity, it may arise during the synthesis or degradation of terazosin and is typically characterized by its molecular structure, which includes specific functional groups that can influence its chemical behavior. The compound may exhibit properties such as solubility in organic solvents, stability under certain conditions, and potential biological activity, although its specific pharmacological effects are less well-documented compared to the parent compound. Analytical techniques such as HPLC (High-Performance Liquid Chromatography) and mass spectrometry are often employed to identify and quantify impurities like Terazosin EP Impurity O in pharmaceutical formulations. Understanding the characteristics of such impurities is crucial for ensuring the safety and efficacy of drug products, as well as for compliance with regulatory standards in pharmaceutical manufacturing.

Formula: C₁₄H₂₂N₂O₄

Synonyms:

• 1,4-Bis[(tetrahydrofuran-2- yl)carbonyl]piperazine
• Terazosin EP IMP O
• Terazosin EP impure O
• Terazosin Impurity17
• Piperazine, 1,4-bis[(tetrahydro-2-furanyl)carbonyl]-
• Terazosin Impurity 3
• 1,4-Bis[(tetrahydrofuran-2-yl)carbo
• Terazosin Impurity 15(Terazosin EP Impurity O)
• piperazine-1,4-diylbis((tetrahydrofuran-2-yl)methanone)
• Terazosin-011
• Terazosin EP Impurity O

Terazosin EP Impurity O (Mixture of Diastereomers)

CAS: 547730-06-3

Formula: C₁₄H₂₂N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 282.34

Ref: 4Z-T-7515

1,4-Bis[(tetrahydrofuran-2-yl)carbonyl]piperazine

Controlled Product

CAS: 547730-06-3

Formula: C₁₄H₂₂N₂O₄

Color and Shape: Neat

Molecular weight: 282.34

Ref: 86-MM0843.16

1,4-Bis[(tetrahydro-2-furanyl)carbonyl]-piperazine

Controlled Product

CAS: 547730-06-3

Impurity Terazosin EP Impurity O
Applications 1,4-Bis[(tetrahydro-2-furanyl)carbonyl]-piperazine (Terazosin EP Impurity O) is a useful synthetic intermediate. It is a derivative of Terazosin (T105000(P)), which is an α-1-adrenergicblocker related to prazosin.
References Patterson, S.E., et al.: J. Chromatog., 311, 206 (1984), Fort, F.L., et al.: Drug Chem. Toxicol., 7, 435 (1984), Lepor, H., et al.: J. Urol., 148, 1467 (1992),

Formula: C₁₄H₂₂N₂O₄

Color and Shape: Neat

Molecular weight: 282.34

Ref: TR-B585325

Terazosin EP Impurity O

CAS: 547730-06-3

Formula: C₁₄H₂₂N₂O₄

Molecular weight: 282.34

Ref: ST-EA-CP-T17015

1,4-Bis[(tetrahydro-2-furanyl)carbonyl]-piperazine

CAS: 547730-06-3

1,4-Bis[(tetrahydro-2-furanyl)carbonyl]-piperazine is a synthetic drug product. It is used as an analytical standard to help elucidate the metabolic pathway of drugs and their metabolites. This compound has been shown to be metabolized by various enzymes including CYP450, glutathione reductase, and esterases. It can also be synthesized from 1,4-dihydropyridine and 2-furancarboxaldehyde. The physical properties of 1,4-bis[(tetrahydro-2-furanyl)carbonyl]-piperazine are: white powder; mp 178°C; IR max 1710 cm−1 (CO); UV max 221 nm (EtOH). The impurities in this product are: 1-(2H)-Quinolinone (CAS No. 2467-94-1) which may have a maximum concentration

Formula: C₁₄H₂₂N₂O₄

Purity: Min. 95%

Molecular weight: 282.34 g/mol

Ref: 3D-IB63853