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CAS 54810-23-0

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Loxapine Hydrochloride

Description:
Loxapine hydrochloride is an antipsychotic medication primarily used in the treatment of schizophrenia and acute manic episodes associated with bipolar disorder. It belongs to the class of drugs known as dibenzoxazepines, which are structurally related to tricyclic antidepressants. The substance acts as a dopamine antagonist, primarily targeting D2 receptors, and also exhibits activity at various serotonin receptors, contributing to its therapeutic effects. Loxapine hydrochloride is typically administered orally or via intramuscular injection, with its pharmacokinetics characterized by moderate absorption and a relatively long half-life. Common side effects may include sedation, dizziness, and extrapyramidal symptoms, which are typical of antipsychotic medications. The drug is contraindicated in patients with a history of hypersensitivity to loxapine or other components of the formulation. As with all antipsychotics, careful monitoring for potential adverse effects and interactions with other medications is essential during treatment.
Formula:C18H19Cl2N3O
InChI:InChI=1/C18H18ClN3O.ClH/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;/h2-7,12H,8-11H2,1H3;1H
SMILES:CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(cc12)Cl.Cl
Synonyms:
  • 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine monohydrochloride
  • Loxapine HCl
  • Loxapine monohydrochloride
  • Loxitane C
  • Loxitane im
  • Unii-376Myl4Mal
  • Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, monohydrochloride
  • 2-Chloro-11-(4-Methylpiperazin-1-Yl)Dibenzo[B,F][1,4]Oxazepine Hydrochloride (1:1)
  • Loxapine hydrochloride
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