CAS 548472-68-0

Nutlin 3

Description:

Nutlin-3 is a small molecule inhibitor that specifically targets the interaction between the p53 tumor suppressor protein and its negative regulator, MDM2. This compound is classified as a potential anticancer agent due to its ability to reactivate p53, leading to cell cycle arrest and apoptosis in cancer cells that retain wild-type p53. Nutlin-3 is characterized by its relatively high selectivity for MDM2 over MDMX, another regulator of p53, which enhances its therapeutic potential. The compound is typically administered in a research setting and has been studied in various cancer models, demonstrating efficacy in inducing p53-mediated responses. Nutlin-3 is a member of the nutlin family of compounds, which are known for their structural features that facilitate binding to the MDM2 protein. Its chemical structure includes a bicyclic core, contributing to its ability to disrupt protein-protein interactions. Overall, Nutlin-3 represents a promising avenue for cancer therapy, particularly in tumors where p53 functionality is intact.

Formula: C₃₀H₃₀Cl₂N₄O₄

InChI: InChI=1/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/s2

InChI key: InChIKey=BDUHCSBCVGXTJM-YBFHJACQNA-N

SMILES: C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)N5CC(=O)NCC5

Synonyms:

• 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
• 2-piperazinone, 4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
• N 6287
• Nutlin 3
• Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
• cis-4-[[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-yl]carbonyl]piperazin-2-one
• rel-4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

Nutlin-3

CAS: 548472-68-0

Nutlin-3

Purity: ≥98%

Molecular weight: 581.49g/mol

Ref: 54-BUP12978

Nutlin-3

CAS: 548472-68-0

Nutlin-3

Purity: 98%

Molecular weight: 581.49g/mol

Ref: 54-OR1024402

Nutlin-3

CAS: 548472-68-0

Formula: C₃₀H₃₀Cl₂N₄O₄

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 581.49

Ref: 7W-GL3688

Nutlin-3

CAS: 548472-68-0

Formula: C₃₀H₃₀Cl₂N₄O₄

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 581.49

Ref: 3B-N1195

Nutlin-3

CAS: 548472-68-0

Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction and activates p53. Nutlin-3 has antitumor activity. Cost-effective and quality-assured.

Formula: C₃₀H₃₀Cl₂N₄O₄

Purity: 98.13% - 99.89%

Color and Shape: Solid

Molecular weight: 581.49

Ref: TM-T2158

Nutlin 3A

CAS: 548472-68-0

Antagonist of proto-oncogene MDM2 and its interaction with p53

Formula: C₃₀H₃₀Cl₂N₄O₄

Purity: Min. 95%

Molecular weight: 581.49 g/mol

Ref: 3D-FN65107

(+/-)-Nutlin-3

Controlled Product

CAS: 548472-68-0

Applications (+/-)-Nutlin-3 is a small molecule MDM2 antagonist.
References Vassilev, L.T., et. al.: Sci., 303, 844 (2004)

Formula: C₃₀H₃₀Cl₂N₂O₄

Color and Shape: Neat

Molecular weight: 580.5

Ref: TR-N925535