CAS 54925-71-2

2'-TBDMS-rU

Description:

2'-TBDMS-rU, or 2'-O-(tert-butyldimethylsilyl)uridine, is a modified nucleoside that features a uridine base with a tert-butyldimethylsilyl (TBDMS) protecting group at the 2' hydroxyl position. This modification enhances the stability of the nucleoside, making it less susceptible to hydrolysis, which is particularly useful in synthetic applications and biochemical studies. The presence of the TBDMS group allows for selective deprotection under specific conditions, facilitating further chemical modifications or incorporation into oligonucleotides. 2'-TBDMS-rU is often utilized in RNA synthesis and research, particularly in studies involving RNA structure and function. Its molecular structure contributes to its solubility and reactivity, making it a valuable tool in nucleic acid chemistry. Additionally, the compound is characterized by its ability to participate in hydrogen bonding, which is crucial for its interactions in biological systems. Overall, 2'-TBDMS-rU serves as an important building block in the field of nucleic acid research and synthetic chemistry.

Formula: C₁₅H₂₆N₂O₆Si

Synonyms:

• 2'-O-(tert-butyldiMethylsilyl)uridine

2'-TBDMS-rU

CAS: 54925-71-2

Formula: C₁₅H₂₆N₂O₆Si

Purity: 95%

Molecular weight: 358.4622

Ref: IN-DA00DJLV

1-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 54925-71-2

1-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Purity: 95%

Molecular weight: 358.46g/mol

Ref: 54-OR1002382

1-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 54925-71-2

Purity: 95%

Molecular weight: 358.4660034

Ref: 10-F783717

2'-O-tert-Butyldimethylsilyluridine

CAS: 54925-71-2

2'-O-tert-Butyldimethylsilyluridine is a nucleoside that is used in DNA synthesis, antiviral research, and anticancer therapy. It is synthesized from 2'-deoxyuridine monophosphate (2'-dUMP) with the aid of a phosphoramidite coupling agent. It has shown to be an effective activator in the synthesis of oligonucleotides, which are short chains of nucleotide units that can be used for various purposes including the treatment of cancer cells. These chains are synthesized by linking together individual nucleosides with phosphate molecules at each end. The bonds between these phosphate groups and the sugar-phosphate backbone of the nucleotide units are called phosphodiester bonds. This synthetic process can be used to produce DNA or RNA strands as well as modified versions of these strands such as those that have been synthesized with other chemical groups on their sugar-phosphate backbones.

Formula: C₁₅H₂₆N₂O₆Si

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 358.46 g/mol

Ref: 3D-NB46819