CAS 55-03-8

Levothyroxine sodium

Description:

Levothyroxine sodium, with the CAS number 55-03-8, is a synthetic form of the thyroid hormone thyroxine (T4) used primarily in the treatment of hypothyroidism. It is a white to off-white crystalline powder that is soluble in water and has a molecular formula of C15H11I4NNaO4. The substance acts by increasing the metabolic rate of tissues, influencing protein synthesis, and regulating the metabolism of carbohydrates and fats. Levothyroxine sodium is typically administered orally and is characterized by its high bioavailability and long half-life, allowing for once-daily dosing in most cases. It is essential for maintaining normal growth and development, particularly in children, and plays a critical role in energy metabolism. The drug's potency can be affected by various factors, including the presence of food, other medications, and individual patient characteristics. As with any medication, monitoring of thyroid hormone levels is crucial to ensure therapeutic effectiveness and to avoid potential side effects associated with over- or under-treatment.

Formula: C₁₅H₁₁I₄NO₄·Na

InChI: InChI=1S/C15H11I4NO4.Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;/h1-2,4-5,12,21H,3,20H2,(H,22,23);/t12-;/m0./s1

InChI key: InChIKey=BRLSOHUOWVCKNI-YDALLXLXSA-N

SMILES: O(C1=CC(I)=C(O)C(I)=C1)C2=C(I)C=C(C[C@@H](C(O)=O)N)C=C2I.[Na]

Synonyms:

• <span class="text-smallcaps">L</span>-Thyroxin Henning
• <span class="text-smallcaps">L</span>-Thyroxine monosodium salt
• <span class="text-smallcaps">L</span>-Thyroxine sodium
• <span class="text-smallcaps">L</span>-Thyroxine sodium salt
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)
• Berlthyrox
• Dathroid
• Droxine
• Eferox
• Elthyrone
• Elthyroxine
• Eltroxin
• Euthyrox
• Eutirox
• L-Thyroxine sodium
• L-Thyroxine sodium salt
• Laevoxin
• Letrox
• Letter
• Levaxin
• Leventa
• Levo-T
• Levolet
• Levoroxine
• Levothroid
• Levothyrox
• Levotirox
• Levotiroxina
• Levoxyl
• Monosodium thyroxine
• NSC 259940
• Novothyrox
• Oroxine
• Puran T 4
• Sodium 2-Amino-3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3,5-Diiodophenyl]Propanoate
• Sodium 4-O-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodo-L-Tyrosine
• Sodium <span class="text-smallcaps">L</span>-thyroxine
• Sodium levothyroxine
• Sodium thyroxin
• Sodium thyroxinate
• Sodium thyroxine
• Synthroid
• Synthroid sodium
• Synthrox
• T 4Kp
• T4 Montpellier 100
• Thevier
• Throxinique
• Thyradin
• Thyradin S
• Thyrax Duotab
• Thyrex
• Thyro 4
• Thyrosit
• Thyroxevan
• Thyroxine sodium
• Thyroxine sodium salt
• Thyroxine, monosodium salt, <span class="text-smallcaps">L</span>-
• Tiroidine
• Tirosint
• Unithroid
• tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)

Levothyroxine sodium impurity standard

CAS: 55-03-8

Levothyroxine sodium impurity standard

Color and Shape: Off-White

Ref: 47-1284

L-Thyroxine sodium

CAS: 55-03-8

L-Thyroxine sodium

Formula: C₁₅H₁₀I₄NO₄·Na

Purity: ≥98%

Molecular weight: 798.85

Ref: 54-BUP18449

L-Thyroxine sodium

CAS: 55-03-8

Formula: C₁₅H₁₀I₄NNaO₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 798.8518

Ref: IN-DA00I9TF

L-Thyroxine sodium

CAS: 55-03-8

L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.

Formula: C₁₅H₁₀I₄NO₄·Na

Purity: 98.74% - 99.86%

Color and Shape: Solid

Molecular weight: 798.85

Ref: TM-T22355

Levothyroxine Sodium

CAS: 55-03-8

Formula: C₁₅H₁₀I₄NO₄Na

Molecular weight: 775.87 : 23.0

Ref: ST-EA-CP-L18037

Thyroxine Sodium Salt

Controlled Product

CAS: 55-03-8

Stability Hygroscopic
Applications One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976), Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988), Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996), Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997),

Formula: C₁₅H₁₀I₄NO₄·Na

Color and Shape: Neat

Molecular weight: 798.85

Ref: TR-T425601