CAS 55-40-3

(±)-Methyldopa

Description:

(±)-Methyldopa, with the CAS number 55-40-3, is an alpha-2 adrenergic agonist primarily used as an antihypertensive agent. It is a white to off-white crystalline powder that is soluble in water and exhibits a melting point typically around room temperature. The compound is a prodrug, meaning it is metabolized in the body to its active form, alpha-methyl norepinephrine, which exerts its therapeutic effects by stimulating central alpha-adrenergic receptors, leading to decreased sympathetic outflow and reduced blood pressure. Methyldopa is characterized by its chiral nature, existing as a racemic mixture of two enantiomers, which contributes to its pharmacological activity. It is often administered orally and can be used in various populations, including pregnant women, due to its favorable safety profile. However, it may cause side effects such as sedation, dry mouth, and potential liver function alterations. Overall, (±)-Methyldopa remains an important medication in the management of hypertension, particularly in specific patient groups.

Formula: C₁₀H₁₃NO₄

InChI: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)

InChI key: InChIKey=CJCSPKMFHVPWAR-UHFFFAOYSA-N

SMILES: C(C(C(O)=O)(C)N)C1=CC(O)=C(O)C=C1

Synonyms:

• (±)-Methyldopa
• (±)-α-Methyldopa
• 2-(3,4-Dihydroxybenzyl)-2-aminopropanoic acid
• 2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
• 2-Azaniumyl-3-(3,4-dihydroxyphenyl)-2-methylpropanoate
• 3-Hydroxy-Beta-Methyltyrosine
• 3-Hydroxy-alpha-methyltyrosine
• 3-Hydroxy-α-methyl-<span class="text-smallcaps">D</smallcap><smallcap>L</span>-tyrosine
• <span class="text-smallcaps">DL</span>-2-Methyl-3-(3,4-dihydroxyphenyl)alanine
• <span class="text-smallcaps">DL</span>-Methyldopa
• <span class="text-smallcaps">DL</span>-α-Methyl DOPA
• <span class="text-smallcaps">DL</span>-α-Methyl-3-(3,4-dihydroxyphenyl)alanine
• Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-
• Metholes
• Mulfasin
• Racemic α-methyldopa
• Tyrosine, 3-hydroxy-α-methyl-

RACEMIC METHYLDOPA CRS

CAS: 55-40-3

RACEMIC METHYLDOPA CRS

Formula: C₁₀H₁₃NO₄

Color and Shape: Powder.

Molecular weight: 211.2145

Ref: 41-Y0001374

3-Hydroxy-α-methyl-dl-tyrosine

CAS: 55-40-3

Formula: C₁₀H₁₃NO₄

Color and Shape: Solid

Molecular weight: 211.2145

Ref: IN-DA003BDN

DL-Methyldopa-d3

CAS: 55-40-3

Formula: C₁₀H₁₀D₃NO₄

Color and Shape: Off-White Solid

Molecular weight: 214.24

Ref: 4Z-D-3226

rac α-Methyl DOPA

Controlled Product

CAS: 55-40-3

Applications Antihypertensive agent.
References Beckett, et al.: J. Pharm. Pharmacol., 7, 433 (1955), Sletzinger, et al.: J. Med. Chem., 6, 101 (1963),

Formula: C₁₀H₁₃NO₄

Color and Shape: Neat

Molecular weight: 211.21

Ref: TR-M303800

Racemate Methyldopa

CAS: 55-40-3

Formula: C₁₀H₁₃NO₄

Molecular weight: 211.22

Ref: ST-EA-CP-M93005

Methyldopa anhydrous

CAS: 55-40-3

Methyldopa anhydrous is a Central alpha-2 Adrenergic Agonist. The mechanism of action of methyldopa anhydrous is as an Adrenergic alpha2-Agonist.

Formula: C₁₀H₁₃NO₄

Color and Shape: Solid

Molecular weight: 211.21

Ref: TM-T69105