CAS 55-92-5: Methacholine

Description:Methacholine is a synthetic choline ester and a muscarinic agonist, primarily used in medical diagnostics to assess airway hyperreactivity in conditions like asthma. It is a quaternary ammonium compound, which means it carries a positive charge at physiological pH, influencing its solubility and permeability. Methacholine acts on muscarinic acetylcholine receptors, leading to bronchoconstriction and increased mucus secretion in the airways. Its chemical structure includes a methyl group attached to the nitrogen atom of the choline moiety, which distinguishes it from acetylcholine. Methacholine is typically administered via inhalation for bronchial provocation tests, allowing clinicians to evaluate airway responsiveness. Due to its pharmacological effects, it can cause side effects such as bronchospasm, increased salivation, and gastrointestinal disturbances. Safety precautions are necessary when using methacholine, particularly in patients with known respiratory conditions. Overall, methacholine serves as a valuable tool in respiratory medicine, aiding in the diagnosis and management of asthma and other reactive airway diseases.

Formula:C₈H₁₈NO₂

InChI:InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1

InChI key:InChIKey=NZWOPGCLSHLLPA-UHFFFAOYSA-N

SMILES:O=C(OC(C)C[N+](C)(C)C)C