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CAS 55-97-0

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Hexamethonium bromide

Description:
Hexamethonium bromide is a quaternary ammonium compound characterized by its use as a ganglionic blocker in pharmacology. It is a white to off-white crystalline powder that is soluble in water and exhibits a strong ionic nature due to the presence of the bromide ion. The compound acts primarily by inhibiting the transmission of nerve impulses in the autonomic nervous system, particularly at the ganglia, which makes it useful in the treatment of hypertension and other conditions related to autonomic dysfunction. Hexamethonium bromide has a relatively low toxicity profile but can cause side effects such as hypotension, dry mouth, and constipation due to its systemic effects on the autonomic nervous system. Its mechanism of action involves competitive antagonism at nicotinic acetylcholine receptors, leading to a decrease in sympathetic and parasympathetic activity. While it has historical significance in clinical settings, its use has declined with the advent of more selective and safer antihypertensive agents.
Formula:C12H30N2·2Br
InChI:InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChI key:InChIKey=FAPSXSAPXXJTOU-UHFFFAOYSA-L
SMILES:C([N+](C)(C)C)CCCCC[N+](C)(C)C.[Br-]
Synonyms:
  • 1,6-Bis(trimethylammonium)hexane dibromide
  • 1,6-Hexanebis(trimethylammonium) dibromide
  • 1,6-Hexanediaminium, N,N,N,N′,N′,N′-hexamethyl-, dibromide
  • 1,6-Hexanediaminium, N<sup>1</sup>,N<sup>1</sup>,N<sup>1</sup>,N<sup>6</sup>,N<sup>6</sup>,N<sup>6</sup>-hexamethyl-, bromide (1:2)
  • Ammonium, hexamethylenebis[trimethyl-, dibromide
  • Bistrium bromide
  • Esametina
  • Gangliostat
  • Hexamethone bromide
  • Hexamethonium bromide hydrate
  • See more synonyms
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