CAS 55-97-0

Hexamethonium bromide

Description:

Hexamethonium bromide is a quaternary ammonium compound characterized by its use as a ganglionic blocker in pharmacology. It is a white to off-white crystalline powder that is soluble in water and exhibits a strong ionic nature due to the presence of the bromide ion. The compound acts primarily by inhibiting the transmission of nerve impulses in the autonomic nervous system, particularly at the ganglia, which makes it useful in the treatment of hypertension and other conditions related to autonomic dysfunction. Hexamethonium bromide has a relatively low toxicity profile but can cause side effects such as hypotension, dry mouth, and constipation due to its systemic effects on the autonomic nervous system. Its mechanism of action involves competitive antagonism at nicotinic acetylcholine receptors, leading to a decrease in sympathetic and parasympathetic activity. While it has historical significance in clinical settings, its use has declined with the advent of more selective and safer antihypertensive agents.

Formula: C₁₂H₃₀N₂·2Br

InChI: InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

InChI key: InChIKey=FAPSXSAPXXJTOU-UHFFFAOYSA-L

SMILES: C([N+](C)(C)C)CCCCC[N+](C)(C)C.[Br-]

Synonyms:

• 1,6-Bis(trimethylammonium)hexane dibromide
• 1,6-Hexanebis(trimethylammonium) dibromide
• 1,6-Hexanediaminium, N,N,N,N′,N′,N′-hexamethyl-, dibromide
• 1,6-Hexanediaminium, N¹,N¹,N¹,N⁶,N⁶,N⁶-hexamethyl-, bromide (1:2)
• Ammonium, hexamethylenebis[trimethyl-, dibromide
• Bistrium bromide
• Esametina
• Gangliostat
• Hexamethone bromide
• Hexamethonium bromide hydrate
• Hexamethonium dibromide
• Hexamethylenebis(trimethylammonium bromide) hydrate
• Hexamethylenebis(trimethylammonium) dibromide
• Hexamethylenebis[trimethylammonium bromide]
• Hexameton
• Hexameton bromide
• Hexane-1,6-bis(trimethylammonium bromide)
• Hexanium bromide
• Hexonium dibromide
• Methobromin
• Methobromine
• N,N,N,N',N',N'-Hexamethylhexane-1,6-diammonium dibromide
• N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium dibromide
• N,N,N,N′,N′,N′-Hexamethyl(hexamethylene)diammonium bromide
• Simpatoblock
• Vegolysen
• Vegolysin
• C 6

Hexamethonium Bromide

CAS: 55-97-0

Formula: C₁₂H₃₀Br₂N₂

Purity: >98.0%(T)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 362.19

Ref: 3B-H0481

Hexamethonium bromide, 98+%

CAS: 55-97-0

Nicotinic acetyl choline receptor antagonist

Formula: C₁₂H₃₀Br₂N₂

Purity: 98+%

Molecular weight: 362.19

Ref: 02-J60466

Hexamethonium Bromide

CAS: 55-97-0

Hexamethonium Bromide blocks neural nicotinic AChR, poorly absorbed in the gut, doesn't pass the blood-brain barrier.

Formula: C₁₂H₃₀Br₂N₂

Purity: 99.76%

Color and Shape: White Crystalline Powder And Agglomerates

Molecular weight: 362.19

Ref: TM-T0287

Hexamethonium bromide

CAS: 55-97-0

Formula: C₁₂H₃₀Br₂N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 362.1880

Ref: IN-DA003QWJ

N1,N1,N1,N6,N6,N6-Hexamethylhexane-1,6-Diaminium Bromide

CAS: 55-97-0

N1,N1,N1,N6,N6,N6-Hexamethylhexane-1,6-Diaminium Bromide

Purity: 98%

Molecular weight: 362.19g/mol

Ref: 54-OR1014191

Hexamethonium Bromide

CAS: 55-97-0

Hexamethonium Bromide

Purity: ≥98%

Molecular weight: 362.19g/mol

Ref: 54-BUP18906

Hexamethonium Bromide

Controlled Product

CAS: 55-97-0

Applications Hexamethonium bromide is a nicotinic ACh receptor antagonist.

Formula: C₁₂H₃₀Br₂N₂

Color and Shape: Neat

Molecular weight: 362.19

Ref: TR-H296708

Hexamethonium bromide

CAS: 55-97-0

Purity: 98%

Molecular weight: 360.078

Ref: 10-F842708