CAS 550-81-2

Amopyroquine

Description:

Amopyroquine, with the CAS number 550-81-2, is an antimalarial compound that belongs to the class of 4-aminoquinolines. It is structurally related to chloroquine and exhibits similar pharmacological properties, primarily used in the treatment and prevention of malaria. The compound functions by interfering with the heme detoxification process in the malaria parasite, leading to the accumulation of toxic heme and ultimately causing parasite death. Amopyroquine is characterized by its ability to penetrate biological membranes, allowing it to reach intracellular targets effectively. It has a moderate solubility in water and is typically administered in oral form. While it has shown efficacy against certain strains of malaria, its use may be limited by potential side effects, including gastrointestinal disturbances and, in rare cases, retinal toxicity. As with many antimalarials, resistance can develop, necessitating careful monitoring of its effectiveness in endemic regions. Overall, Amopyroquine represents an important option in the arsenal against malaria, particularly in areas where resistance to other treatments is prevalent.

Formula: C₂₀H₂₀ClN₃O

InChI: InChI=1S/C20H20ClN3O/c21-15-3-5-17-18(7-8-22-19(17)12-15)23-16-4-6-20(25)14(11-16)13-24-9-1-2-10-24/h3-8,11-12,25H,1-2,9-10,13H2,(H,22,23)

InChI key: InChIKey=YNWCUCSDUMVJKR-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(Cl)C=C2)N=CC1)C3=CC(CN4CCCC4)=C(O)C=C3

Synonyms:

• 4-(7-Chloro-4-Quinolylamino)-Alpha-Pyrrolidin-1-Yl-O-Cresol
• 4-(7-Chloroquinolin-1-ylamino)-2-(1-pyrrolidinylmethyl)phenol
• 4-[(7-Chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)phenol
• 4-[(7-Chloro-4-quinolyl)amino]-α-1-pyrrolidinyl-o-cresol
• 4-[(7-Chloroquinolin-4-Yl)Amino]-2-(Pyrrolidin-1-Ylmethyl)Phenol
• Amopyroquin
• Pam-780
• Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-
• Propoquin
• o-Cresol, 4-[(7-chloro-4-quinolyl)amino]-α-1-pyrrolidinyl-

Amopyroquine

CAS: 550-81-2

Amopyroquine is an antimalarial agent and is used for the treatment of malaria. Its mode of action involves the inhibition of haem polymerase in the parasite, leading to the accumulation of toxic haem

Formula: C₂₀H₂₀ClN₃O

Purity: Min. 95%

Color and Shape: Slightly Yellow Powder

Molecular weight: 353.85 g/mol

Ref: 3D-FA17882

Amopyroquine

Controlled Product

CAS: 550-81-2

Applications Antimalarial agent. The compound showed antimalarial activity similar to that of Chloroquine.
References Desjardins, R., et al.: Antimicrob. Agents Chemother., 16, 710 (1979), McKie, J., et al.: J. Med. Chem., 41, 1367 (1998), Gozalbes, R., et al.: J. Pharm. Pharmacol., 52, 111 (1999), Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 1293 (2005),

Formula: C₂₀H₂₀ClN₃O

Color and Shape: Neat

Molecular weight: 353.85

Ref: TR-A634215