CAS 55079-83-9: Acitretin
Description:Acitretin is a synthetic retinoid, primarily used in the treatment of severe psoriasis and other skin disorders. It is a derivative of vitamin A and functions by modulating cellular growth and differentiation, particularly in keratinocytes. Acitretin is characterized by its ability to reduce hyperproliferation of skin cells and normalize the differentiation process, leading to improved skin appearance and reduced scaling. The compound is typically administered orally and is known for its long half-life, which can lead to prolonged effects even after discontinuation. Acitretin is also associated with a range of side effects, including mucocutaneous dryness, potential liver toxicity, and teratogenic effects, necessitating strict contraceptive measures in women of childbearing age during and after treatment. Due to its pharmacological properties, Acitretin is classified as a category X drug in pregnancy. Its mechanism of action involves binding to retinoic acid receptors, influencing gene expression related to skin cell proliferation and differentiation. Overall, Acitretin is a potent therapeutic agent with specific applications and safety considerations in dermatological practice.
Formula:C21H26O3
InChI:InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
InChI key:InChIKey=IHUNBGSDBOWDMA-AQFIFDHZSA-N
SMILES:O=C(O)C=C(C=CC=C(C=CC=1C(=CC(OC)=C(C1C)C)C)C)C
- Synonyms:
- (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
- (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
- (2Z,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
- 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, (2E,4E,6E,8E)-
- 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, (all-E)-
- 9-(4-Methoxy-2,3,6-Trimethylphenyl)-3,7-Dimethyl-2,4,6,8-Nonatetraenoic Acid
- Acitretin
- Acitretinoin
- Etretine
- Etretino
- See more synonyms
- Neotigason
- Ro 10-1670
- Ro 10-1670/000
- Soriatane
- Tmmp
- all-trans-Acitretin
- Etretin
