CAS 55079-83-9

Acitretin

Description:

Acitretin is a synthetic retinoid, primarily used in the treatment of severe psoriasis and other skin disorders. It is a derivative of vitamin A and functions by modulating cellular growth and differentiation, particularly in keratinocytes. Acitretin is characterized by its ability to reduce hyperproliferation of skin cells and normalize the differentiation process, leading to improved skin appearance and reduced scaling. The compound is typically administered orally and is known for its long half-life, which can lead to prolonged effects even after discontinuation. Acitretin is also associated with a range of side effects, including mucocutaneous dryness, potential liver toxicity, and teratogenic effects, necessitating strict contraceptive measures in women of childbearing age during and after treatment. Due to its pharmacological properties, Acitretin is classified as a category X drug in pregnancy. Its mechanism of action involves binding to retinoic acid receptors, influencing gene expression related to skin cell proliferation and differentiation. Overall, Acitretin is a potent therapeutic agent with specific applications and safety considerations in dermatological practice.

Formula: C₂₁H₂₆O₃

InChI: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+

InChI key: InChIKey=IHUNBGSDBOWDMA-AQFIFDHZSA-N

SMILES: C(=C/C(=C/C=C/C(=C/C(O)=O)/C)/C)\C1=C(C)C(C)=C(OC)C=C1C

Synonyms:

• (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
• (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• (2Z,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, (2E,4E,6E,8E)-
• 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, (all-E)-
• 9-(4-Methoxy-2,3,6-Trimethylphenyl)-3,7-Dimethyl-2,4,6,8-Nonatetraenoic Acid
• Acitretin
• Acitretinoin
• Etretine
• Etretino
• Neotigason
• Ro 10-1670
• Ro 10-1670/000
• Soriatane
• Tmmp
• all-trans-Acitretin

Acitretin

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow to Green powder to crystal

Molecular weight: 326.44

Ref: 3B-A3097

Acitretin

CAS: 55079-83-9

Color and Shape: Neat

Ref: 61-FOR3427.00

ACITRETIN CRS

CAS: 55079-83-9

ACITRETIN CRS

Formula: C₂₁H₂₆O₃

Color and Shape: Yellow. Crystalline Powder. Powder.

Molecular weight: 326.4293

Ref: 41-A0225000

Acitretin

CAS: 55079-83-9

Acitretin

Formula: C₂₁H₂₆O₃

Purity: 100.0%

Color and Shape: Light Yellow To Light Green

Molecular weight: 326.18819

Ref: 47-827

Acitretin

CAS: 55079-83-9

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Formula: C₂₁H₂₆O₃

Color and Shape: Powder

Molecular weight: 326.43 g/mol

Ref: 45-1011007

Acitretin

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 326.4293

Ref: IN-DA00390E

Acitretin

CAS: 55079-83-9

Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

Formula: C₂₁H₂₆O₃

Purity: 98.60% - 99.13%

Color and Shape: Crystals From Hexane Solid

Molecular weight: 326.43

Ref: TM-T1330

Acitretin

CAS: 55079-83-9

Acitretin

Purity: 99%

Molecular weight: 326.43g/mol

Ref: 54-OR1027209

Acitretin

CAS: 55079-83-9

Acitretin

Purity: ≥98%

Molecular weight: 326.43g/mol

Ref: 54-BUP16739

Acitretin

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Color and Shape: Yellow Solid

Molecular weight: 326.44

Ref: 4Z-A-582

Acitretin, EP grade

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Purity: ≤ 0.3%

Color and Shape: Yellow or green-yellow crystalline powder

Molecular weight: 326.43

Ref: 7W-GP5421

Acitretin-d3

CAS: 55079-83-9

Formula: C₂₁H₂₃D₃O₃

Color and Shape: Yellow Solid

Molecular weight: 329.45

Ref: 4Z-A-583

Acitretin

Controlled Product

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Color and Shape: Neat

Molecular weight: 326.43

Ref: 04-C10032000

Acitretin

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Purity: 95%~99%

Molecular weight: 326.436

Ref: BP-BP4001

Acitretin

Controlled Product

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Color and Shape: Neat

Molecular weight: 326.43

Ref: 86-MM3427.00

Acitretin

CAS: 55079-83-9

Formula: C₂₁H₂₆O₃

Purity: ≥ 98.0% (dried basis)

Color and Shape: Yellow or green-yellow crystalline powder

Molecular weight: 326.43

Ref: 7W-GP9248

Acitretin

Controlled Product

CAS: 55079-83-9

Stability Light Sensitive
Applications A synthetic retinoid which is the major metabolite of Etretinate (E938000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Liu, X., et al.: Cancer Chemother. Pharmacol., 63, 167 (2008),

Formula: C₂₁H₂₆O₃

Color and Shape: Light Yellow To Light Green

Molecular weight: 326.43

Ref: TR-A189900

Acitretin

Controlled Product

CAS: 55079-83-9

Retinoid;activates nuclear retinoid acid receptor; antineoplastic; anti-psoratic

Formula: C₂₁H₂₆O₃

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 326.43 g/mol

Ref: 3D-FA11039

Acitretin - Bio-X ™

Controlled Product

CAS: 55079-83-9

Acitretin is a synthetic retinoid that can be used to treat skin conditions such as acne, psoriasis, and eosinophilic fasciitis. It has been shown to be an active inhibitor of squamous cell carcinoma in the laboratory. Acitretin works by inhibiting the excessive cell growth and keratinisation seen in psoriasis therefore reducing the thickening of the skin, plaque formation and scaling.

Formula: C₂₁H₂₆O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 326.43 g/mol

Ref: 3D-BA164136

ACITRETIN

CAS: 55079-83-9

Purity: 98%

Molecular weight: 326.4360046

Ref: 10-F799738